Table 3 Sensitivity analysis for the genome-wide significant hits in the meta-analysis across both stages
From: Epigenome-wide association study of lung function in Latino children and youth with asthma
Probe | Model | Puerto Ricans | Mexicans | Meta-analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coef | SE | P | CQP | Coef | SE | P | CQP | Coef | SE | P | CQP | ||
cg16405908 | M0 | − 2.53E−02 | 5.05E−03 | 5.13E−07 | 2.48E−01 | − 1.79E−02 | 5.70E−03 | 1.64E−03 | 7.87E−01 | − 2.21E−02 | 3.78E−03 | 5.02E−09 | 5.02E−01 |
M1 | − 1.75E−02 | 5.99E−03 | 3.40E−03 | 8.09E−01 | − 2.45E−02 | 5.18E−03 | 2.33E−06 | 2.98E−01 | − 2.15E−02 | 3.92E−03 | 4.06E−08 | 5.93E−01 | |
M2 | − 1.70E-02 | 5.75E−03 | 3.17E−03 | 9.94E−01 | − 2.63E−02 | 5.35E−03 | 8.54E−07 | 2.99E−01 | − 2.20E−02 | 3.92E−03 | 1.97E−08 | 4.76E−01 | |
M3 | − 1.79E-02 | 5.77E−03 | 1.93E−03 | 8.63E−01 | − 2.54E−02 | 5.08E−03 | 5.69E−07 | 2.54E−01 | − 2.21E−02 | 3.81E−03 | 6.50E−09 | 5.16E−01 | |
M4 | − 1.83E-02 | 6.02E−03 | 2.33E−03 | 9.32E−01 | − 2.49E−02 | 5.06E−03 | 8.73E−07 | 2.36E−01 | − 2.22E−02 | 3.87E−03 | 1.04E−08 | 5.50E−01 | |
M5 | − 1.77E-02 | 5.78E−03 | 2.15E−03 | 7.22E−01 | − 2.57E−02 | 5.04E−03 | 3.55E−07 | 2.41E−01 | − 2.22E−02 | 3.80E−03 | 4.77E−09 | 4.64E−01 | |
M6 | − 1.86E-02 | 5.74E−03 | 1.22E−03 | 6.95E−01 | − 2.50E−02 | 5.10E−03 | 9.14E−07 | 2.21E−01 | − 2.22E−02 | 3.81E−03 | 5.95E−09 | 5.01E−01 | |
M7 | − 1.87E-02 | 6.46E−03 | 3.86E−03 | 8.96E−01 | − 2.36E−02 | 5.66E−03 | 3.03E−05 | 2.11E−01 | − 2.15E−02 | 4.26E−03 | 4.62E−07 | 5.90E−01 | |
cg07428101 | M0 | 7.21E-03 | 1.47E−03 | 8.72E−07 | 6.55E−01 | 5.64E−03 | 2.04E−03 | 5.70E−03 | 4.64E−01 | 6.68E−03 | 1.19E−03 | 2.05E−08 | 7.71E−01 |
M1 | 5.65E-03 | 2.15E−03 | 8.61E−03 | 6.04E−01 | 6.91E−03 | 1.50E−03 | 3.93E−06 | 5.84E−01 | 6.50E−03 | 1.23E−03 | 1.23E−07 | 8.50E−01 | |
M2 | 4.62E-03 | 1.91E−03 | 1.57E−02 | 6.79E−01 | 7.13E−03 | 1.57E−03 | 5.93E−06 | 6.70E−01 | 6.11E−03 | 1.22E−03 | 4.87E−07 | 7.10E−01 | |
M3 | 5.88E-03 | 2.07E−03 | 4.58E−03 | 4.20E−01 | 7.24E−03 | 1.47E−03 | 9.03E−07 | 6.66E−01 | 6.78E−03 | 1.20E−03 | 1.64E−08 | 7.72E−01 | |
M4 | 5.51E-03 | 2.22E−03 | 1.32E−02 | 3.45E−01 | 7.29E−03 | 1.48E−03 | 8.49E−07 | 6.69E−01 | 6.75E−03 | 1.23E−03 | 4.44E−08 | 6.78E−01 | |
M5 | 5.18E-03 | 2.05E−03 | 1.14E−02 | 2.86E−01 | 7.24E−03 | 1.47E−03 | 8.04E−07 | 7.14E−01 | 6.54E−03 | 1.19E−03 | 4.14E−08 | 5.84E−01 | |
M6 | 5.81E-03 | 2.12E−03 | 6.10E−03 | 6.48E−01 | 7.02E−03 | 1.49E−03 | 2.60E−06 | 6.11E−01 | 6.62E−03 | 1.22E−03 | 5.89E−08 | 8.77E−01 | |
M7 | 4.68E-03 | 2.22E−03 | 3.49E−02 | 5.99E−01 | 6.36E−03 | 1.69E−03 | 1.71E−04 | 5.85E−01 | 5.74E−03 | 1.35E−03 | 1.98E−05 | 8.16E−01 | |
cg06035600 | M0 | 3.35E-01 | 6.89E−02 | 1.15E−06 | 6.11E−01 | 1.81E−01 | 6.22E−02 | 3.69E−03 | 8.84E−01 | 2.50E−01 | 4.62E−02 | 6.13E−08 | 3.83E−01 |
M1 | 3.38E-01 | 7.29E−02 | 3.51E−06 | 5.64E−01 | 1.78E−01 | 6.23E−02 | 4.31E−03 | 8.72E−01 | 2.46E−01 | 4.74E−02 | 2.17E−07 | 3.70E−01 | |
M2 | 3.51E-01 | 7.23E−02 | 1.24E−06 | 7.26E−01 | 1.57E−01 | 6.52E−02 | 1.59E−02 | 7.88E−01 | 2.44E−01 | 4.84E−02 | 4.72E−07 | 2.46E−01 | |
M3 | 3.34E-01 | 6.91E−02 | 1.30E−06 | 5.08E−01 | 1.64E−01 | 6.25E−02 | 8.63E−03 | 8.73E−01 | 2.41E−01 | 4.63E−02 | 2.05E−07 | 2.83E−01 | |
M4 | 3.06E-01 | 7.24E−02 | 2.45E−05 | 9.92E−01 | 1.76E−01 | 6.18E−02 | 4.30E−03 | 9.31E−01 | 2.31E−01 | 4.70E−02 | 9.08E−07 | 6.05E−01 | |
M5 | 3.38E-01 | 6.99E−02 | 1.35E−06 | 5.80E−01 | 1.93E−01 | 6.26E−02 | 2.05E−03 | 9.23E−01 | 2.58E−01 | 4.67E−02 | 3.39E−08 | 4.41E−01 | |
M6 | 3.02E-01 | 7.02E−02 | 1.68E−05 | 8.44E−01 | 1.79E−01 | 6.27E−02 | 4.30E−03 | 8.77E−01 | 2.34E−01 | 4.68E−02 | 5.86E−07 | 6.20E−01 | |
M7 | 3.09E-01 | 8.78E−02 | 4.41E−04 | 8.14E−01 | 1.51E−01 | 6.62E−02 | 2.21E−02 | 7.30E−01 | 2.08E−01 | 5.29E−02 | 8.05E−05 | 5.29E−01 | |
cg00914963 | M0 | − 2.53E-02 | 4.96E−03 | 3.33E−07 | 6.70E−01 | − 1.08E−02 | 4.55E−03 | 1.77E−02 | 7.24E−02 | − 1.89E−02 | 5.76E−03 | 1.04E−07 | 4.50E−02 |
M1 | − 2.70E-02 | 5.13E−03 | 1.47E−07 | 9.72E−01 | − 9.98E−03 | 4.72E−03 | 3.44E−02 | 6.19E−02 | − 1.99E−02 | 6.44E−03 | 1.10E−07 | 2.41E−02 | |
M2 | − 2.49E-02 | 4.97E−03 | 5.51E−07 | 2.69E−01 | − 1.17E−02 | 1.19E−02 | 5.66E−02 | 2.09E−02 | − 1.73E−02 | 7.33E−03 | 3.77E−07 | 5.02E−03 | |
M3 | − 2.46E-02 | 4.98E−03 | 7.73E−07 | 6.30E−01 | − 1.04E−02 | 4.55E−03 | 2.18E−02 | 6.74E−02 | − 1.84E−02 | 5.74E−03 | 2.66E−07 | 4.62E−02 | |
M4 | − 2.92E-02 | 4.77E−03 | 9.43E−10 | 8.75E−01 | − 1.16E−02 | 4.51E−03 | 9.92E−03 | 9.80E−02 | − 2.15E−02 | 6.18E−03 | 4.06E−10 | 1.91E−02 | |
M5 | − 2.57E-02 | 5.03E−03 | 3.30E−07 | 7.70E−01 | − 1.06E−02 | 4.55E−03 | 2.03E−02 | 9.03E−02 | − 1.88E−02 | 5.76E−03 | 1.44E−07 | 4.77E−02 | |
M6 | − 2.31E-02 | 5.09E−03 | 5.63E−06 | 2.79E−01 | − 1.08E−02 | 4.64E−03 | 2.05E−02 | 6.91E−02 | − 1.64E−02 | 3.43E−03 | 1.83E−06 | 5.28E−02 | |
M7 | − 2.94E-02 | 5.40E−03 | 5.16E−08 | 4.47E−01 | − 1.05E−02 | 1.30E−02 | 9.29E−02 | 1.64E−02 | − 1.89E−02 | 8.90E−03 | 1.01E−07 | 1.01E−03 | |
cg20515679 | M0 | − 1.86E-01 | 1.35E−01 | 2.58E−06 | 3.54E−04 | − 8.53E−02 | 2.59E−02 | 9.90E−04 | 4.04E−01 | − 1.24E−01 | 4.84E−02 | 1.13E−07 | 1.94E−03 |
M1 | − 1.83E-01 | 1.35E−01 | 2.78E−06 | 4.47E−04 | − 8.96E−02 | 2.65E−02 | 7.13E−04 | 5.04E−01 | − 1.26E−01 | 4.91E−02 | 8.80E−08 | 2.55E−03 | |
M2 | − 1.85E-01 | 1.36E−01 | 5.02E−06 | 3.84E−04 | − 8.76E−02 | 2.63E−02 | 8.67E−04 | 4.05E−01 | − 1.24E−01 | 4.83E−02 | 1.79E−07 | 2.42E−03 | |
M3 | − 1.95E-01 | 1.31E−01 | 5.58E−07 | 4.10E−04 | − 8.32E−02 | 2.60E−02 | 1.37E−03 | 4.81E−01 | − 1.28E−01 | 4.89E−02 | 3.89E−08 | 1.60E−03 | |
M4 | − 2.14E-01 | 1.59E−01 | 8.13E−06 | 2.90E−04 | − 8.15E−02 | 2.60E−02 | 1.68E−03 | 4.47E−01 | − 1.28E−01 | 5.10E−02 | 8.87E−07 | 1.75E−03 | |
M5 | − 1.94E-01 | 1.42E−01 | 1.24E−06 | 2.05E−04 | − 8.51E−02 | 2.61E−02 | 1.12E−03 | 4.23E−01 | − 1.27E−01 | 5.06E−02 | 7.13E−08 | 1.12E−03 | |
M6 | − 1.97E-01 | 1.40E−01 | 7.92E−06 | 5.76E−04 | − 8.42E−02 | 2.58E−02 | 1.12E−03 | 4.27E−01 | − 1.25E−01 | 4.78E−02 | 4.34E−07 | 3.13E−03 | |
M7 | − 2.21E-01 | 1.44E−01 | 7.86E−05 | 4.00E−03 | − 8.46E−02 | 2.70E−02 | 1.73E−03 | 6.83E−01 | − 1.27E−01 | 4.52E−02 | 6.22E−06 | 1.82E−02 | |