Table 2 Association results for the probes that showed consistent association in Mexican Americans and Puerto Ricans from GALA II
From: Epigenome-wide association study of lung function in Latino children and youth with asthma
Trait | Discovery/replication | Probe | Gene | Discovery | Replication | Meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coef | SE | P | FDR | Coef | SE | P | Coef | SE | P | ||||
Post-FVC | PR/MX | cg16405908 | MRGPRE | − 2.53 × 10−2 | 5.05 × 10−3 | 5.13 × 10−7 | 0.071 | − 1.79 × 10−2 | 5.70 × 10−3 | 1.64 × 10−3 | − 2.21 × 10−2 | 3.78 × 10−3 | 5.02 × 10−9 |
Post-FVC | PR/MX | cg07428101 | MUC2 | 7.21 × 10−3 | 1.47 × 10−3 | 8.72 × 10−7 | 0.071 | 5.64 × 10−3 | 2.04 × 10−3 | 5.70 × 10−3 | 6.68 × 10−3 | 1.19 × 10−3 | 2.05 × 10−8 |
Post-FVC | PR/MX | cg00129273 | PRDM14 | − 5.86 × 10−2 | 5.28 × 10−2 | 1.16 × 10−6 | 0.071 | − 4.27 × 10−2 | 1.69 × 10−2 | 1.17 × 10−2 | − 5.24 × 10−2 | 2.59 × 10−2 | 1.80 × 10−7 |
Pre-FEV1 | MX/PR | cg18573338 | TBC1D17 | 8.71 × 10−3 | 8.42 × 10−3 | 7.38 × 10−7 | 0.061 | 2.62 × 10−3 | 1.32 × 10−3 | 4.64 × 10−2 | 5.32 × 10−3 | 2.97 × 10−3 | 2.20 × 10−6 |
Pre-FEV1 | MX/PR | cg18635207 | TMEM90A | 4.22 × 10−3 | 4.04 × 10−3 | 8.56 × 10−7 | 0.061 | 1.17 × 10−3 | 5.78 × 10−4 | 4.37 × 10−2 | 2.45 × 10−3 | 1.35 × 10−3 | 2.32 × 10−6 |
Pre-FVC | MX/PR | cg10523319 | DHRS3 | 6.55 × 10−3 | 1.25 × 10−3 | 1.70 × 10−7 | 0.012 | 2.38 × 10−3 | 3.22 × 10−3 | 3.01 × 10−2 | 4.70 × 10−3 | 2.10 × 10−3 | 1.31 × 10−7 |
Pre-FEV1/FVC | MX/PR | cg06035600 | MAP3K6 | 3.35 × 10−1 | 6.89 × 10−2 | 1.15 × 10−6 | 0.068 | 1.81 × 10−1 | 6.22 × 10−2 | 3.69 × 10−3 | 2.50 × 10−1 | 4.62 × 10−2 | 6.13 × 10−8 |
Pre-FEV1/FVC | MX/PR | cg01408486 | CXXC5 | 1.12 × 10−1 | 2.42 × 10−2 | 3.51 × 10−6 | 0.068 | 4.79 × 10−2 | 2.13 × 10−2 | 2.45 × 10−2 | 7.60 × 10−2 | 1.60 × 10−2 | 2.02 × 10−6 |
Post-FVC | MX/PR | cg00914963 | TBC1D16 | − 2.53 × 10−2 | 4.96 × 10−3 | 3.33 × 10−7 | 0.016 | − 1.08 × 10−2 | 4.55 × 10−3 | 1.77 × 10−2 | − 1.89 × 10−2 | 5.76 × 10−3 | 1.04 × 10−7 |
Post-FVC | MX/PR | cg22467052 | CFTR | 8.01 × 10−3 | 6.09 × 10−3 | 2.15 × 10−6 | 0.044 | 3.44 × 10−3 | 1.35 × 10−3 | 1.10 × 10−2 | 5.76 × 10−3 | 2.55 × 10−3 | 6.03 × 10−7 |
Post-FEV1/FVC | MX/PR | cg20515679 | KCNJ6 | − 1.86 × 10−1 | 1.35 × 10−1 | 2.58 × 10−6 | 0.046 | − 8.53 × 10−2 | 2.59 × 10−2 | 9.90 × 10−4 | − 1.24 × 10−1 | 4.84 × 10−2 | 1.13 × 10−7 |
Post-FEV1/FVC | MX/PR | cg25637972 | RBM24/STMND1 | 7.28 × 10−2 | 1.56 × 10−2 | 3.13 × 10−6 | 0.051 | 4.37 × 10−2 | 1.63 × 10−2 | 7.42 × 10−3 | 5.89 × 10−2 | 1.13 × 10−2 | 1.79 × 10−7 |