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Table 2 Treatment-related adverse events

From: Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis

Treatment-related adverse events (%, N = 30)

Grade 1

Grade 2

Grade 3

General

 Nausea

27

0

0

 Fatigue

17

7

0

 Fever

3

0

0

 Emesis

3

0

0

 Dehydration

3

0

0

 Anorexia

7

0

0

 Cough

3

0

0

 Pain

3

0

0

 Hypoalbuminemia

3

3

0

Hematologic

 Anemia

7

0

3

 Leukopenia

7

3

0

 Lymphopenia

3

7

0

 Neutropenia

7

0

0

 Thrombocytopenia

3

0

0

Gastrointestinal

 Constipation

0

10

0

 Flatulence

3

0

0

 Diarrhea

3

0

0

Hepatic

 ALT elevation

10

3

3

 Alkaline phosphatase elevation

3

0

0

 AST elevation

3

0

3

Dermatologic

 Injection site reaction

7

0

0

 Ecchymosis

3

0

0

 Rash

3

0

0

Others

 Renal dysfunction

0

3

0

 Hypoxia

3

0

0

 Bradycardia

3

0

0

 Headache

3

0

0

 Stroke

3

0

0