Fig. 5

CD8⁺ TIL density. A TIL density in all evaluable pre-treatment and on-treatment samples, plotted on log scale. B Change in TIL density within individual pairs of tumors from pre- to on-treatment, plotted on log scale. Patient 4 (PR) had no assessable tumor on post-treatment biopsy. C Difference in TIL density within each patient’s tumor pairs, plotted with mean and SEM. D Pre-treatment TIL density in patients who benefitted versus patients who did not benefit from treatment, plotted with mean and SEM. *p < 0.05