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Table 4 Associations between mtDNAcn and D-loop methylation levels

From: Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL

D-loop methylation

mtDNAcn

Crude β (95% CI)

P

Adjusted β (95% CI)

Pa

Total

 Tertile 1

Reference

 

Reference

 

 Tertile 2

 − 12.23 (− 22.71,− 1.75)

0.022

 − 14.39 (− 24.35,− 4.42)

0.005

 Tertile 3

 − 8.79 (− 11.99,− 5.59)

 < 0.001

 − 9.11(− 12.33,− 5.88)

 < 0.001

 P for Trend

 

 < 0.001

 

 < 0.001

 Continuous

 − 5.15 (− 7.24,− 3.07)

 < 0.001

 − 5.74 (− 7.80,− 3.69)

 < 0.001

Male

 Tertile 1

    

 Tertile 2

 − 15.86 (− 24.66,− 4.07)

 < 0.001

 − 16.61(− 25.28,− 7.95)

 < 0.001

 Tertile 3

 − 10.01(− 15.62,− 4.41)

0.001

 − 10.65 (− 16.10,− 5.19)

 < 0.001

 P for Trend

 

 < 0.001

 

 < 0.001

 Continuous

 − 4.18 (− 6.95,− 1.42)

0.003

 − 4.32 (− 7.04,− 1.60)

0.019

Female

 Tertile 1

    

 Tertile 2

 − 17.03 (− 29.46,− 4.60)

0.007

 − 19.55 (− 32.96,− 6.14)

0.004

 Tertile 3

 − 9.99 (− 13.70,− 6.28)

 < 0.001

 − 10.44 (− 14.08,− 6.81)

 < 0.001

 P for Trend

 

 < 0.001

 

 < 0.001

 Continuous

 − 7.73 (− 10.77,− 4.68)

 < 0.001

 − 7.65 (− 10.56,− 4.74)

 < 0.001

  1. aAdjust for gender, age, hypertension, diabetes mellitus, dyslipidemia
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Clinical Epigenetics

ISSN: 1868-7083

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