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Table 3 The differences of D-loop region methylation levels between CADASIL group and control group

From: Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL

 

D-loop region methylation

Crude β (95% CI)

P

Adjusted β (95% CI)

Pa

Total

 − 1.49 (− 2.08,− 0.90)

 < 0.001

 − 1.46 (− 2.04,− 0.87)

 < 0.001

Male

 − 0.86 ( − 1.58,− 0.15)

0.018

 − 0.88 (− 1.60,− 0.16)

0.017

Female

 − 2.59 ( − 3.52,− 1.66)

 < 0.001

 − 2.86 (− 3.88,− 1.84)

 < 0.001

  1. aAdjust for gender, age, hypertension, diabetes mellitus, dyslipidemia