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Table 3 CIMP status and risk of cervical lesion

From: The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer

 

CIMP

OR

CI

P

Negative

n

High

n

Non-SIL

16

2

1

  

LSIL

43

1

0.19

0.003–3.92

0.141

HSIL

1

15

120

7.95–5342.9

0.0000

CC

1

25

200

13.75–8683.9

0.0000

Non-SIL

16

2

1

  

HSIL and CC

2

40

160

16.64–1960.8

0.0000

Non-SIL and LSIL

59

3

1

  

HSIL and CC

2

40

393.3

52.9–4040.78

0.0000

 

Negative + low

n

High

n

   

Non-SIL

57

2

1

  

LSIL

107

1

0.27

0.004–5.26

0.251

HSIL

14

15

30.5

5.77–290-09

0.0000

CC

26

25

27.4

5.91–248.19

0.0000

  1. Significant values for associations are indicated in bold
  2. CIMP, CpG island methylation phenotype; OR, odd ratio; CI, confidence interval; CC, cervical cancer; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; Non-SIL, negative for squamous intraepithelial lesion