The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer

Table 1 Sociodemographic and sexual conduct characteristics associated with precancerous lesions and cervical cancer

	Non-SIL		LSIL		HSIL		CC		P
	n = 58	%	n = 107	%	n = 29	%	n = 51	%	P
Age (years)^a	37.59 ± 10.97		35.78 ± 11.94		39.37 ± 13.29		57.12 ± 13.18		0.001^b
Range	19–68		19–74		20–63		31–84
Smoking status
No	52	89.66	89	83.18	24	82.76	35	68.63	0.042^c
Yes	6	10.34	15	14.02	3	10.34	10	19.61
Unknown	0	0.0	3	2.80	2	6.90	6	11.76
Alcohol consumption
No	31	53.45	54	50.47	20	68.97	36	70.59	< 0.001^c
Yes	27	46.55	50	46.73	7	24.14	9	17.65
Unknown	0	0.0	3	2.80	2	6.90	6	11.76
Parity
None	33	55.93	62	57.94	6	20.69	2	3.92	< 0.001^c
1–2	18	30.51	26	24.30	4	13.79	5	9.80
3–5	6	10.17	16	14.95	7	24.14	17	33.33
≥ 6	1	1.69	0	0.0	8	27.59	25	49.02
Unknown	1	1.69	3	2.80	4	13.79	2	3.92
Sexual age of onset
< 16	3	5.08	12	11.21	5	17.24	16	31.37	< 0.001^c
16–20	39	66.10	53	49.53	19	65.52	24	47.06
> 20	16	27.12	40	37.38	3	10.34	8	15.69
Unknown	1	1.69	2	1.87	2	6.90	3	5.88
Number of life time sexual partners
1–2	48	81.36	75	70.09	22	75.86	35	68.63	0.056^c
≥ 3	10	16.95	28	26.17	4	13.79	9	17.65
Unknown	1	1.69	4	3.74	3	10.34	7	13.73
Education (years)
0	0	0.0	3	2.80	7	24.14	19	37.25	< 0.001^c
6	2	3.39	7	6.54	7	24.14	22	43.14
9	4	6.78	8	7.48	3	10.34	0	0.0
12	5	8.47	15	14.02	1	3.45	5	9.80
≥ 13	48	81.36	70	65.42	9	31.03	1	1.96
Unknown	0	0.0	4	3.74	2	6.90	4	7.84

CC cervical cancer, HSIL high-grade squamous intraepithelial lesion, LSIL low-grade squamous intraepithelial lesion, Non-SIL negative for squamous intraepithelial lesion
^aExpressed as mean ± standard deviation
^bKruskal-Wallis
^cchi-squared

ISSN: 1868-7083