Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights

Table 1 List of epi-drugs used in this study

Type	Target	Drug	References
HDACi	HDAC1	Quisinostat	[23]
HDACi	SIRT1	Selisistat, Nicotinamide	[25, 28]
HDMi	KDM1A/LSD1/AOF2	GSK2879552, Bizine	[30, 33]
	KDM2A/FBXL11	Daminozide	[32]
	KDM5A/JARID1A	JIB-04	[35]
	KDM5B/JARID1B	PBIT	[26]
HMTi	SUV39H1	Chaetocin	[31]
PAHi	BRD4	MZ-1	[37]
	BRD7	LP99, VZ185	[36, 38]
	BRD9	LP99, VZ185, BI-9564	[29, 36, 38]
PRC1i	RING1	PRT4165	[27]
PRC2i	EZH2	GSK343	[34]
DNMTi	DNMT1	Aurintricarboxylic acid	[24]

Type of target, target name, drug name and reference are indicated. HDACi: histone deacetylase inhibitor, HDMi: histone demethylase inhibitor, HMTi: histone methyltransferase inhibitor, PAHi: inhibitor of proteins binding to acetylated histones, PRCi: polycomb-repressive complex inhibitor, DNMTi: DNA methyltransferase inhibitor

ISSN: 1868-7083