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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights

Fig. 3

Epi-drugs induced deregulations of genes associated with glycoproteins, ion transporters and DNA-binding factors. A PCA of the RNA seq data performed in 2102EP 16 h after treatment with the epi-drugs (DMSO control n = 3, epi-drugs n = 1). B Diagram illustrating the number of deregulated genes and correlating fold-changes in gene expression after each epi-drug treatment. Only deregulated genes with an FDR corrected p value of < 0.05 were considered. The gray bar indicates genes below the fold change of log2 1.5. C Word clouds representing the ten most significant functional annotations of up- or downregulated gene ontologies (filtered by uncorrected p value < 0.05). Letter sizes correlate with − log10 (p value). For more data, see Additional file 12: Table S2 B–H

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