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Table 4 Mediation analysis of GrimAge acceleration for the TG/HDL-C and CAC associationsa

From: Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

 

Total effect

Mediation effect

Direct effect

Percent mediated (%)

P value

TG Year0

0.023

0.003

0.019

14.0

0.070

TG Year5

0.023

0.006

0.017

22.5

0.046

TG Year10

0.024

0.006

0.017

25.2

0.041

TG Year15

0.030

0.005

0.026

14.3

0.005

TG Year20

0.031

0.004

0.027

11.2

0.013

Cumulative TG

0.030

0.006

0.024

17.4

0.005

HDL-C Year0

− 0.014

− 0.004

− 0.009

15.3

0.583

HDL-C Year5

− 0.018

− 0.007

− 0.011

23.9

0.469

HDL-C Year10

− 0.034

− 0.007

− 0.027

19.4

0.194

HDL-C Year15

− 0.048

− 0.012

− 0.036

25.3

0.117

HDL-C Year20

− 0.028

− 0.007

− 0.021

19.4

0.312

Cumulative HDL-C

− 0.037

− 0.010

− 0.027

25.1

0.181

  1. aModel adjusted for center, sex, race, education, alcohol drinking, and physical activity
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Clinical Epigenetics

ISSN: 1868-7083

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