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Table 2 Associations between cumulative TG and HDL-C from Y0 to Y15, and GrimAge accelerationa,b

From: Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

  

Estimate (yr/SD)

Standard error

95% CI

P

TG

Total

0.730

0.122

0.426

1.034

< 0.0001

 

Male

0.614

0.205

0.205

0.956

0.0025

 

Female

0.900

0.189

0.521

1.278

< 0.0001

 

Black

1.110

0.211

0.687

1.585

< 0.0001

 

White

0.518

0.194

0.130

0.842

0.0049

HDL-C

Total

− 0.569

0.165

− 0.881

− 0.275

0.0002

 

Male

− 0.321

0.196

− 0.695

0.053

0.09

 

Female

− 0.776

0.215

− 1.189

− 0.380

0.0002

 

Black

− 0.643

0.297

− 1.203

− 0.066

0.03

 

White

− 0.503

0.174

− 0.851

− 0.155

0.005

  1. aDifference in GrimAge acceleration (in years) per each 1-SD higher cumulative TG/HDL-C
  2. bModel adjusted for center, sex, race, education, alcohol drinking, and physical activity
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Clinical Epigenetics

ISSN: 1868-7083

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