A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer

Clinical Epigenetics

Table 3 Univariate and multivariate logistic regression of LNM in the modeling cohort

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	OR (95% CI)	p value	OR (95% CI)	p value
Age, years (≤ 60 vs. > 60)	2.56 (1.45–4.53)	0.001
Gender (Male vs. Female)	1.27 (0.74–2.17)	0.368
Tumor size, mm (> 20 vs. ≤ 20)	1.63 (1.04–2.54)	0.032
Differentiation (Undifferentiated vs. Differentiated)	3.88 (1.83–8.20)	< 0.001	3.85 (1.94–7.67)	< 0.001
Invasional depth (SM vs. M)	3.37 (2.01–6.58)	< 0.001	2.48 (1.41–4.36)	0.002
Tumor location
Low versus Upper	1.37 (0.57–3.27)	0.486
Middle versus Upper	0.64 (0.32–3.13)	0.676
LVI (Presence vs. Absence)	11.95 (5.53–25.83)	< 0.001	11.30 (5.40–23.64)	< 0.001
Ulceration (Presence vs. Absence)	2.76 (1.60–4.74)	< 0.001	2.36 (1.39–4.00)	0.001
3-Marker methylation (Risk score)	16.13 (8.29–31.39)	< 0.001		< 0.001

OR, odds ratio; CI, confidence interval; M, mucosa; SM, submucosa; LVI, lymphovascular invasion

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