Fig. 4
Performance of the 3-marker methylation model compared to preoperative CT imaging and clinicopathological features. a, b ROC curves of 3-marker methylation model as compared to those of CT imaging and clinicopathological features including tumor size, lymphovascular invasion, invasional depth, ulceration, and differentiation type in the model development and validation cohorts, respectively. Comparison of AUC values was conducted by DeLong test. c, d The accuracy of the 3-marker methylation model as compared to CT imaging and individual clinicopathological features in the model development and validation cohorts, respectively. Statistical significance was assessed by χ2 test. *p < 0.05, **p < 0.01, ***p < 0.001