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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles

Fig. 4

Blood levels of biomarkers measured by routine clinical tests can be used to accurately diagnosis SAP during its early stage. A SAP prediction accuracy by undiscriminatingly using 75 available measures from 93 body fluids-measuring clinical tests; B 12 venous blood-based tests identified from the training set built an SAP model that classified test set MAP and SAP samples with high accuracy; C members of the 12-biomarker model may either positively or negatively predict SAP. D When being incorporated to SAP prediction model using aggregate uMHL scores of cfDNA, the 12 venous biomarkers significantly improved its overall prediction accuracy. SAP, severe acute pancreatitis; cfDNA, cell free DNA; MAP, mild acute pancreatitis; uMHL, unmethylated haplotype load

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Clinical Epigenetics

ISSN: 1868-7083

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