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Table 2 Sensitivity and specificity of the ctDNA methylation test and CEA in patients with tumor load

From: Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer

Biopsy finding

ctDNA methylation test (n = 804)*

n

Positive results (n)

Negative results (n)

Sensitivity %

Specificity %

Stage I

7

6

1

85.7

 

Stage II

43

32

11

74.4

 

Stage III

125

104

21

83.2

 

Stage IV

227

197

30

86.8

 

Total

402

339

63

84.3

 

Normal controls

402

22

380

 

94.5