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Table 1 Sensitivity and specificity of the cfDNA paired ctDNA methylation test and CEA in patients with tumor load and normal controls

From: Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer

Biopsy finding ctDNA methylation test (n = 612)* CEA test (n = 612) *
n Positive results (n) Negative results (n) Sensitivity % Specificity % n Positive results (n) Negative results (n) Sensitivity % Specificity %
Stage I 3 3 0 100.0   3 0 3 0.0  
Stage II 32 21 11 65.6   32 9 23 28.1  
Stage III 85 66 19 77.6   85 35 50 41.2  
Stage IV 185 161 24 87.0   185 123 62 66.5  
Total 305 251 54 82.3   305 167 138 54.8  
Normal controls 307 14 293   95.4 307 9 298   97.1
  1. *Patients with tumor load were included in the sensitivity analysis