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Table 1 Sensitivity and specificity of the cfDNA paired ctDNA methylation test and CEA in patients with tumor load and normal controls

From: Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer

Biopsy finding

ctDNA methylation test (n = 612)*

CEA test (n = 612) *

n

Positive results (n)

Negative results (n)

Sensitivity %

Specificity %

n

Positive results (n)

Negative results (n)

Sensitivity %

Specificity %

Stage I

3

3

0

100.0

 

3

0

3

0.0

 

Stage II

32

21

11

65.6

 

32

9

23

28.1

 

Stage III

85

66

19

77.6

 

85

35

50

41.2

 

Stage IV

185

161

24

87.0

 

185

123

62

66.5

 

Total

305

251

54

82.3

 

305

167

138

54.8

 

Normal controls

307

14

293

 

95.4

307

9

298

 

97.1

  1. *Patients with tumor load were included in the sensitivity analysis
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Clinical Epigenetics

ISSN: 1868-7083

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