Reproductive history and blood cell DNA methylation later in life: the Young Finns Study

Clinical Epigenetics

Table 5 Methylation age acceleration and pregnancy history before 2011 (n = 896)

	Age acceleration residual — Horvath			Age acceleration residual — Hannum			Age acceleration — PhenoAge			Age acceleration — Grimage
Parity	beta	SE	p	beta	SE	p	beta	SE	p	beta	SE	p
0			0.31			0.70	0.00		0.68	0.00		0.36
1	− 0.93	0.53		− 0.20	0.45		0.51	0.65		− 0.14	0.41
2	− 0.27	0.46		0.25	0.39		0.67	0.56		− 0.40	0.35
3 +	− 0.12	0.51		0.17	0.43		0.31	0.61		− 0.63	0.39
History of low birthweight	0.19	0.86	0.83	− 1.11	0.73	0.13	1.58	1.00	0.12	0.91	0.60	0.13
History of preterm birth	0.10	0.65	0.87	− 0.26	0.55	0.64	1.06	0.76	0.16	− 0.34	0.46	0.46
History of any hypertensive disorder	− 0.94	0.70	0.18	− 0.21	0.59	0.73	− 0.98	0.81	0.23	− 0.53	0.49	0.28
History of pregnancy-induced hypertension	− 0.57	1.08	0.60	− 0.63	0.92	0.49	0.11	1.26	0.93	− 1.03	0.76	0.18
History of pre-eclampsia	− 0.01	1.48	0.99	− 0.49	1.26	0.70	1.28	1.73	0.46	− 0.14	1.04	0.89
History of gestational diabetes	0.39	0.77	0.62	0.05	0.65	0.94	0.08	0.90	0.93	0.44	0.54	0.42
History of miscarriage	− 0.34	0.50	0.50	0.31	0.42	0.47	0.71	0.58	0.22	0.03	0.35	0.94

ISSN: 1868-7083