Methylation-derived inflammatory measures and lung cancer risk and survival

Clinical Epigenetics

Table 3 Correlations between methylation-based CRP scores and circulating log-CRP level, log-IL6 level, peripheral blood leukocyte types, BMI, and smoking score residual among controls only

	Score 1^b	Score 2^c	Score 3^d
	Spearman (p value)	Spearman (p value)	Spearman (p value)
Pancreatic cancer study (controls only)
Log-CRP level^a	0.284 (4.27e−06)	0.247 (6.96e−05)	0.297 (1.56e−06)
Log-IL6 level^a	0.213 (7.53e−04)	0.158 (1.32e−02)	0.203 (1.33e−03)
CLUE I/II (controls only)
CD4T	0.425 (1.65e−10)	0.359 (1.00e−07)	0.212 (2.13e−03)
CD8T	0.504 (8.78e−15)	0.461 (2.34e−12)	0.390 (5.74e−09)
NK	0.062 (3.70e−01)	0.175 (1.17e−02)	0.026 (7.09e−01)
B cell	0.103 (1.38e−01)	0.069 (3.23e−01)	− 0.027 (6.99e−01)
Neutrophils	− 0.467 (1.19e−12)	− 0.422 (2.24e−10)	− 0.264 (1.17e−04)
Monocytes	− 0.292 (1.92e−05)	− 0.330 (1.17e−06)	− 0.288 (2.38e−05)
mdNLR	− 0.488 (7.66e−14)	− 0.449 (1.01e−11)	− 0.281 (3.96e−05)
BMI	0.025 (7.22e−01)	0.070 (3.12e−01)	− 0.063 (3.68e−01)
Methylation-predicted pack-years residual^e	0.475 (4.46e−13)	0.375 (2.43e−08)	0.632 (1.42e−24)

^aCorrelations with log-CRP level and log-IL6 level were tested with a pancreatic cancer dataset[43]
^bCpG Score 1 is built using 54 CpG sites
^cCpG Score 2 is built using the top 10 highly cell-specific CpG sites
^dCpG Score 3 is built using the 10 modestly cell-specific CpG sites
^eWe calculated a pack-years methylation score to represent pack-years smoked associated methylation alterations. This score correlates with gene expression changes that are affected by smoking

ISSN: 1868-7083