Table 1 Baseline characteristics of lung cancer cases and matched controls nested in CLUE I/II

N

208

208

150

29

Median age (range, years)

56 [28, 81]

59 [30, 83]

58 [36, 83]

53 [30, 71]

Median time before diagnosis (range, years)

14 [0, 29]

14 [0, 28]

12 [2, 29]

Sex

 Male

95 (45.7%)

95 (45.7%)

61 (40.7%)

16 (55.2%)

 Female

113 (54.3%)

113 (54.3%)

89 (59.3%)

13 (44.8%)

Race

 White

208 (100%)

205 (98.6%)

149 (99.3%)

28 (96.6%)

 Black

0 (0%)

3 (1.4%)

1 (0.7%)

1 (3.4%)

Cigarette smoking status

 Never smoker

22 (10.6%)

22 (10.6%)

15 (10.0%)

1 (3.4%)

 Ever smoker

80 (38.5%)

80 (38.5%)

56 (37.3%)

10 (34.5%)

 Current smoker

106 (51.0%)

106 (51.0%)

79 (52.7%)

18 (62.1%)

Median cigarette smoking Intensity (range, cig/day)

20 [0, 80]

20 [0, 80]

20 [0, 70]

20 [0, 80]

Cigar or pipe smoking

Never

176 (84.6%)

178 (85.6%)

132 (88.0%)

25 (86.2%)

Ever

28 (13.5%)

26 (12.5%)

15 (10.0%)

4 (13.8%)

Current

4 (1.9%)

4 (1.9%)

3 (2.0%)

0 (0%)

Median BMI, kg/m² (range)

25.8 [18.0, 40.9]

25.6 [15.5, 42.6]

25.4 [15.5, 42.6]

25.6 [18.3, 34.7]

mdNLR mean (SD)

1.74 (0.976)

1.86 (1.32)

1.85 (1.19)

1.65 (1.07)

mdNLR median (range)

1.58 [0.13, 6.42]

1.59 [0.28, 11.90]

1.56 [0.28, 9.45]

1.44 [0.39, 4.81]

CRP score 1 mean (SD)

0.02 (1.01)

− 0.02 (0.99)

− 0.04 (0.97)

0.47 (1.08)

CRP score 1 median (range)

0.06 [− 2.42, 2.99]

− 0.03 [− 3.26, 2.94]

− 0.03 [− 3.26, 2.94]

0.41 [− 1.93, 2.16]

CRP score 2 mean (SD)

0.04 (1.03)

− 0.04 (0.98)

− 0.06 (0.95)

0.36 (1.17)

CRP score 2 median (range)

0.01 [− 3.35, 3.93]

− 0.10 [− 2.68, 3.10]

− 0.11 [− 2.68, 3.10]

0.24 [− 2.34, 3.10]

CRP score 3 mean (SD)

− 0.06 (0.98)

0.06 (1.02)

0.09 (1.03)

0.32 (0.97)

CRP score 3 median (range)

− 0.09 [− 2.43, 2.51]

0.08 [− 2.34, 2.95]

0.10 [− 2.34, 2.95]

0.38 [− 2.19, 1.97]