DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Table 4 List of significant differentially methylated CpGs associated with various CMD markers identified on meta-analysis

Gambian				Indian			Meta-analysis							Gene
CpG	Coef	P value	FDR	Coef	P value	FDR	Effect	SE	P value	FDR	Direction	HetI²	HetI² ^{p value}
Insulinogenic index
cg04859490	− 0.037	9.71 × 10^–02	0.950	− 0.045	8.75 × 10^–08	0.070	− 0.044	0.008	4.38 × 10^–08	0.029	–	0	0.721	CPA4
cg00363845	− 0.062	8.13 × 10^–06	0.284	− 0.036	5.54 × 10^–04	0.711	− 0.046	0.009	7.30 × 10^–08	0.029	–	51.7	0.150	GTPBP3/ ANO8
Pulse pressure
cg14997376	0.004	6.63 × 10^–04	0.649	0.005	3.26 × 10^–05	0.581	0.005	0.001	4.25 × 10^–08	0.034	+ +	0	0.700	CIT

Genomic coordinates are all from the hg19 build of the genome. CMD = cardiometabolic disease; Coef = regression coefficient (reported from the regressions using methylation M values); FDR = Benjamini–Hochberg false discovery rate; SE = standard error; HetI², heterogeneity index

ISSN: 1868-7083