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Table 3 List of significant differentially methylated regions associated with various CMD markers

From: DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Chromosome

Start position

End position

Width (bp)

No. of CpGs

Stouffer

p value

Associated gene

Gambian

Systolic blood pressure

chr1

155,099,264

155,099,332

69

3

0.039

EFNA1

Fasting insulin

chr8

144,120,106

144,120,681

576

9

0.010

C8orf31

Indian

Fasting glucose

chr20

49,072,540

49,072,658

119

2

0.026

Intergenic

HOMA2-S

chr22

33,964,297

33,964,309

13

2

0.011

Intergenic

chr20

62,133,588

62,133,626

39

3

0.023

RP4-697K14.3

chr3

194,866,144

194,866,280

137

2

0.024

RN7SL36P

chr1

79,088,559

79,088,769

211

2

0.030

Intergenic

chr6

150,071,069

150,071,503

435

3

0.037

PCMT1

chr1

6,059,070

6,059,204

135

2

0.047

Intergenic

chr1

240,861,557

240,861,571

15

2

0.049

Y_RNA.12

chr10

1,205,222

1,205,942

721

10

0.050

LINC00200

  1. Genomic coordinates are all from the hg19 build of the genome. CMD = cardiometabolic disease; bp = base pairs; HOMA2-S = Insulin Sensitivity