DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Table 2 List of significant differentially methylated CpGs associated with various CMD markers

Traits	CpG ID	Genomic location (hg19)	Gambian			Indian			Gene
Traits	CpG ID	Genomic location (hg19)	Coef	P value	FDR	Coef	P value	FDR	Gene
Gambian dmCpGs
Systolic blood pressure	cg13455829	chr9:136213445	0.054	3.04 × 10^–08	0.015	−0.002	0.747	0.997	MED22
	cg22671726	chr19:41305423	−0.017	3.74 × 10^–08	0.015	0.002	0.515	0.991	EGLN2
	cg00368636	chr7:64734674	0.040	1.64 × 10^–07	0.044	0.005	0.39	0.989	Intergenic
Fasting insulin	cg22388948	chr6:82460558	1.373	1.78 × 10^–08	0.014	0.077	0.598	0.993	FAM46A
	cg13934266	chr15:52029533	−0.132	5.48 × 10^–08	0.022	0.014	0.279	0.979	LYSMD2
Triglycerides	cg15237100	chr15:69755217	−0.439	5.32 × 10^–08	0.031	−0.024	0.318	0.955	RP11-279F6.1/ RP11-253M7.4
LDL-C	cg01469688	chr9:127905934	0.132	8.74 × 10^–09	0.004	0.041	0.019	0.916	SCAI
	cg06952751	chr18:21083211	0.384	9.33 × 10^–09	0.004	0.009	0.999	0.999	C18orf8
	cg27229251	chr7:2680532	0.494	2.29 × 10^–08	0.006	0.015	0.732	0.996	TTYH3
	cg13135286*	chr1:218302163	−4.858	5.07 × 10^–08	0.010	0.033	0.98	0.999	Intergenic
	cg13819288	chr2:119898838	−2.259	2.20 × 10^–07	0.035	0.163	0.392	0.987	Intergenic
	cg07988415	chr4:153291285	2.748	3.12 × 10^–07	0.042	0.303	0.328	0.983	FBXW7
Indian dmCpGs
HOMA2-S	cg10304969	chr1:25795613	0.154	0.387	0.986	−0.734	2.27 × 10^–08	0.018	TMEM57
Insulinogenic index adjusted for HOMA2-S	cg22982428	chr2:216402618	−0.010	0.948	0.999	0.302	2.68 × 10^–08	0.022	Intergenic
HDL-C	cg04988216	chr1:64471626	−0.223	0.190	0.974	−0.956	2.36 × 10^–08	0.019	ROR1

The gene name corresponds to the nearest gene as annotated in the Illumina EPIC array manifest. CMD = cardiometabolic disease; Coef = regression beta coefficient; FDR = Benjamini–Hochberg false discovery rate; LDL-C = Low-Density Lipoprotein Cholesterol; HOMA2-S = Insulin Sensitivity; HDL-C = High-Density Lipoprotein cholesterol; dmCpG = differentially methylated CpG. Regression coefficients were calculated using beta values in the regression models for the dmCpGs to obtain interpretable coefficients
*Denotes the association between the CpG and outcome was confounded by genotype

ISSN: 1868-7083