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Fig. 3 | Clinical Epigenetics

Fig. 3

From: DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study

Fig. 3

Meta-EWAS of Indian and the Gambian cohorts with respect to the Insulinogenic Index. A Manhattan plot of meta-analysis results with respect to the insulinogenic index. Red line indicates the adjusted p value threshold of 0.05. Significant dmCpGs (adjusted p value < 0.05) are highlighted in red and labelled with the gene associated with them. B Volcano plot of the meta-analysis results with respect to the insulinogenic index. Significant CpGs are highlighted in red. C, D Relationship between methylation beta value at C cg04859490 (CPA4) and D cg00363845 (GTPBP3/ANO8) and the insulinogenic index residual in combined dataset (left) and then separated by cohort (right). Shaded area around the regression lines denotes the 95% confidence interval. EWAS, Epigenome-wide association study

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