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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

Fig. 3

Correlation and association of FGFR2 DNA methylation with mRNA expression, HPV status, and sensitivity to FGFR-targeted TKIs. a Genomic context of ten selected CpG sites within FGFR2 included into the present study. The illustration, including the predicted regulatory build [63] and transcription start sites according to the Eponine algorithm [64], was exported from www.ensemble.org [65]. b Methylation levels within the ten selected CpG loci within FGFR2 and mRNA expression levels in NAT and tumor tissues and HPV(−) and HPV(+) tumors. c Spearman’s ρ of correlations between DNA methylation and FGFR2 mRNA expression. d Spearman’s ρ of correlations between FGFR2 DNA methylation and mRNA expression with FGFR2 amplification. e Spearman’s ρ of correlations of FGFR2 DNA methylation, CNV, and mRNA expression with ln(IC50) of PD 173074 and AZD4547. Statistically significant features are marked with asterisks *. P values (corrected and uncorrected) refer to Wilcoxon-Mann–Whitney U test for comparisons and to Spearman’s ρ for correlations analysis, respectively

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