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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors

Fig. 1

Correlation and association of CCND1 DNA methylation with mRNA expression, CCND1 amplification, HPV status, and sensitivity to FGFR-targeted TKIs. a Genomic context of 30 selected CpG sites within CCND1 included into the present study. The illustration, including the predicted regulatory build [63] and transcription start sites according to the Eponine algorithm [64], was exported from www.ensemble.org [65]. b Methylation levels of the 30 selected CpG loci within CCND1 and mRNA expression levels in NATs and tumor tissues, HPV(−) and HPV(+) tumor tissues, and CCND1 amplified and non-amplified tumors. c Spearman’s ρ of correlations between CCND1 DNA methylation and CCND1 mRNA expression. d Spearman’s ρ of correlations between CCND1 DNA methylation and mRNA expression with CCND1 amplification. e Spearman’s ρ of correlations of CCND1 DNA methylation, mRNA expression, and amplification with ln(IC50) of PD 173074 and AZD4547. Statistically significant features are marked with asterisks*. P values (corrected and uncorrected) refer to Wilcoxon-Mann–Whitney U test for comparisons and to Spearman’s ρ for correlations analysis, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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