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Table 1 Univariate and multivariate of Cox proportional hazard modeling of factors associated with survival of CRC patients

From: Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer

Variable Hazard ratio (95% CI) P value
(1) Univariate analysis of overall survival
 Age 0.97 0.93–1.00 0.2
 Gender (female vs. male) 0.86 0.36–2.00 0.7
 TNM stage 2.26 1.23–4.17 0.009
 PMF of UNC5A 1.51 0.35–6.12 0.6
 PMF of UNC5C 5.83 1.43–23.85 0.014
 PMF of UNC5D 6.10 1.48–25.04 0.012
 PMF of Sept9 5.58 1.21–25.63 0.026
(2) Multivariate analysis of overall survival
 TNM stage1 3.39 1.65–6.95 0.001
 PMF of UNC5C1 15.06 3.12–72.65 0.001
 TNM stage2 2.61 1.37–4.98 0.004
 PMF of UNC5D2 10.02 2.13–47.08 0.003
 TNM stage3 2.54 1.26–5.11 0.009
 PMF of Sept93 5.95 1.30–27.24 0.022
(3) Univariate analysis of progress free survival
 Age 1.00 0.97–1.06 1.0
 Gender (female vs. male) 0.94 0.46–1.92 0.9
 TNM stage 1.73 1.07–2.77 0.023
 PMF of UNC5A 1.81 0.62–5.43 0.3
 PMF of UNC5C 3.44 1.12–10.56 0.03
 PMF of UNC5D 4.77 1.48–15.34 0.009
 PMF of Sept9 2.05 0.73–5.81 0.2
(4) Multivariate analysis of progress free survival
 TNM stage4 1.97 1.19–3.26 0.008
 PMF of UNC5C4 4.81 1.50–15.38 0.008
 TNM stage5 1.90 1.15–3.13 0.012
 PMF of UNC5D5 6.17 1.81–20.99 0.004
  1. P ≤ 0.05 is considered statistically significant and shown in bold
  2. 1–5 different comparison groups in Multivariate analysis of survival