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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer

Fig. 3

Verification of methylation-mediated repression of UNC5 receptors in CRC cells. A detection methods established for methylation evaluation. CpG islands spanning the promoter region of UNC5 receptors. Horizontal bars, CpG sites; detection area for BGS and methylight are indicated. TSS, transcription start site; BSP, bisulfite sequencing primers. B BGS results of UNC5 promoters in CRC cell lines treated with 5-aza-2′-deoxycytidine; Circles, CpG sites analyzed; row of circles, individual promoter allele cloned and sequenced; filled circle, methylated CpG sites; open circle, unmethylated CpG site. C, methylight results of UNC5 promoters in CRC cell lines treated with 5-aza-2′-deoxycytidine. Real-time PCR results were displayed correspondingly

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Clinical Epigenetics

ISSN: 1868-7083

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