DNA methylation mediates the association between breastfeeding and early-life growth trajectories

Briollais, Laurent; Rustand, Denis; Allard, Catherine; Wu, Yanyan; Xu, Jingxiong; Rajan, Samyukta Govinda; Hivert, Marie-France; Doyon, Myriam; Bouchard, Luigi; McGowan, Patrick O.; Matthews, Steven; Lye, Steven

doi:10.1186/s13148-021-01209-z

Clinical Epigenetics

Table 2 Top EWAS hits associated with child longitudinal BMI from ALSPAC data in boys and girls selected at the P = 5.10⁻⁷ level

From: DNA methylation mediates the association between breastfeeding and early-life growth trajectories

CpG site	Gene	Chr	Pos. (kb)	Group	P value	EBF effect on DNAm (≥ 3 months vs. 0)^a				EBF direct effect on BMI (≥ 3 months vs. 0)^b				EBF effect on BMI mediated by DNAm (≥ 3 months vs. 0)^c
CpG site	Gene	Chr	Pos. (kb)	Group	P value	1 year	2 years	7 years	15 years	1 year	2 years	7 years	15 years	1 year	2 years	7 years	15 years
Girls
cg06471491	miR-21	17	57,918	TSS1500	< E−16	0.02	− 0.08	− 0.07	− 0.07	− 1.13	− 0.51	− 0.17	− 0.37	0.36	0.11	0.00	0.01
cg16645539	SNAPC3	9	15,423	TSS200	< E−16	− 0.05	− 0.03	0.00	− 0.01	− 0.28	− 0.73	− 0.21	− 0.29	− 0.38	0.00	0.02	0.00
cg07408552	ATP6V0A1	17	40,612	5'UTR	3.E−08	− 0.19	− 0.18	0.06	0.00	− 1.84	− 0.44	− 0.16	− 0.32	− 0.34	− 0.08	0.03	− 0.01
cg08224066	DHX15/PPARGC1A	4	24,578	Body	4.E−08	− 0.04	0.03	0.05	0.05	− 0.30	− 0.44	− 0.20	− 0.30	0.00	0.03	0.00	0.02
cg14822546	LINC00398/ALOX5AP	13	31,381	–	7.E−08	− 0.01	0.01	0.01	− 0.01	− 0.76	− 0.53	− 0.22	− 0.40	0.09	− 0.04	0.01	0.00
cg14776321	FAM238C	10	27,220	Body	7.E−08	− 0.05	− 0.01	0.04	0.04	− 0.10	− 0.43	− 0.12	− 0.30	− 0.30	0.03	0.06	0.02
ch.8.18261148F	NATP/NAT2	8	18,217	–	7.E−08	− 0.11	− 0.06	− 0.03	− 0.04	− 0.66	− 0.67	− 0.19	− 0.26	0.05	0.01	0.00	0.01
cg00313685	CUX1	7	101,469	Body	1.E−07	0.19	0.06	− 0.01	0.05	− 0.39	− 0.14	− 0.22	− 0.30	− 0.10	0.00	− 0.02	− 0.04
cg17476951	TRAPPC9	8	141,054	Body	2.E−07	− 0.12	− 0.06	0.02	0.01	− 0.67	− 0.53	− 0.25	− 0.30	0.13	0.20	0.01	0.00
cg26398656	OSBPL1A	18	21,852	Body TSS200	3.E−07	− 0.11	− 0.06	0.00	0.04	− 0.36	− 0.60	− 0.23	− 0.25	− 0.27	− 0.11	0.03	− 0.01
cg26872564	ZNF185	X	152,087	Body	3.E−07	− 0.06	− 0.01	0.06	0.07	− 0.27	− 0.19	− 0.23	− 0.38	0.04	0.01	0.00	− 0.01
cg18176842	FAM84A	2	14,776	3'UTR	3.E−07	− 0.11	− 0.09	− 0.02	− 0.06	− 0.17	− 0.03	− 0.27	− 0.41	0.10	0.08	0.00	− 0.03
cg04354689	PDPK1	16	2,660	Body	5.E−07	0.19	0.06	− 0.01	0.05	− 0.39	− 0.14	− 0.22	− 0.30	0.14	0.02	− 0.02	0.00
Boys
cg26657240	IL16	15	81,475	–	3.E−07	− 0.02	− 0.02	− 0.03	− 0.03	− 1.43	− 0.39	− 0.01	− 0.06	− 0.01	0.00	0.05	0.23
cg08651538	NREP	5	111,070	Body	4.E−07	− 0.06	− 0.05	− 0.03	0.02	− 1.32	− 0.42	0.02	− 0.07	0.03	0.02	0.00	0.09

^aCorresponds to estimate of β_M(t) in Fig. 1. We estimated the average effect of 3 to 5 months of EBF vs. 0 month
^bCorresponds to estimate of β_DIR(t) in Fig. 1. We estimated the average effect of 3 to 5 months of EBF vs. 0 month
^cCorresponds to estimate of β_IND(t) in Fig. 1. We estimated the average effect of 3 to 5 months of EBF vs. 0 month

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