Table 3 Methylation and expression correlation analysis
Regulatory element | DMR | DEG | Correlation analysis | |||
|---|---|---|---|---|---|---|
Region | Genehancer ID | Direction (smokers–nonsmokers) | Target gene | Direction (smokers–nonsmokers) | P value | |
Promoter | chr12:108733790–108734067 | GH12J108336 | Hyper | CMKLR1 | Down | 0.0108 |
Promoter/enhancer | chr2:222312663–222313620 | GH02J221447 | Hyper | EPHA4 | Up | 0.0130 |
chr2:74375246–74375595 | GH02J074146 | Hyper | AUP1 | Down | 0.0433 | |
chr12:108733790–108734067 | GH12J108336 | Hyper | CMKLR1 | Down | 0.0108 | |
chr12:48289327–48289770 | GH12J047896 | Hyper | DDX23 | Down | 0.0122 | |
chr11:126030937–126031289 | GH11J126157 | Hyper | FAM118B | Down | 0.0181 | |
chr2:74375246–74375595 | GH02J074146 | Hyper | HTRA2 | Down | 0.0433 | |
chr22:22128415–22128928 | GH22J021772 | Hyper | IGLV5-52 | Down | 0.0424 | |
chr19:30158120–30158513 | GH19J029660 | Hyper | PLEKHF1 | Down | 0.0241 | |
chr11:116699588–116699946 | GH11J116825 | Hyper | SIDT2 | Down | 0.0159 | |
chr1:161513847–161514197 | GH01J161539 | Hyper | SLAMF7 | Down | 0.0324 | |
chr11:116699588–116699946 | GH11J116825 | Hyper | TAGLN | Down | 0.0116 | |
chr1:92291397–92291719 | GH01J091825 | Hyper | TGFBR3 | Down | 0.0376 | |
chr5:372991–373651 | GH05J000367 | Hypo | AHRR | Up | 0.0324 | |
chr3:98239609–98240661 | GH03J098521 | Hypo | CLDND1 | Up | 0.0220 | |
chr3:169757128–169757597 | GH03J170037 | Hypo | GPR160 | Up | 0.0131 | |
chr19:19928614–19928997 | GH19J019816 | Hypo | ZNF506 | Up | 0.0348 | |
chr19:38186831–38187042 | GH19J037695 | Hypo | ZNF793 | Up | 0.0194 | |
chr17:73684198–73684529 | GH17J075683 | Hypo | LLGL2 | Down | 0.0316 | |
chr11:67024748–67025170 | GH11J067257 | Hypo | RAD9A | Down | 0.0420 | |
chr9:116164296–116164796 | GH09J113396 | Hypo | RGS3 | Down | 0.0001 | |
chr22:46442102–46442610 | GH22J046040 | Hypo | TTC38 | Down | 0.0179 | |
chr7:148723197–148723699 | GH07J149026 | Hypo | ZNF282 | Down | 0.0220 | |