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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking

Fig. 4

Genes detected in both methylation and RNA expression. A Volcano plot shows the differentially expressed genes between smokers and nonsmokers. Each dot corresponds to a gene and color corresponds to the direction. B Pathway enrichment analysis of DEGs by DisGeNET. C Overlapping genes between DMGs and DEGs. D Pathway enrichment analysis of overlapping genes in methylation and mRNA datasets by DisGeNET. The 20 most significantly enriched pathways are illustrated in dot plots. Gene ratio refers to the proportion of DEGs belonging to a specific term. Node size (count) refers to the number of DEGs within each term and the color indicates the level of significance (− log10 P value). DMGs differentially methylated genes, DEGs differentially expressed genes

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