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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Genome-wide methylation and expression analyses reveal the epigenetic landscape of immune-related diseases for tobacco smoking

Fig. 3

Distribution of SM-DMRs across the whole genome. A Tobacco smoking is associated with DNA methylation changes across the whole genome. Circles represent DNA methylation levels for hypermethylation (outer circle, red) and hypomethylation (inner circle, blue). The height of each bar indicates the methylation change between smokers and nonsmokers. B The distribution ratio and enrichment results of DMRs summarized based on genomic locations. Red and blue bars in the figure represent the SM-DMRs and each grey bar is the average proportion of the 1000 groups of control regions for each genome feature. The significance level and standard deviation are shown in the figure (*P < 0.05, **P < 0.01). C SM-DMRs enrichment results of epigenomic annotations in different cell types and tissues based on Roadmap Epigenomics Project. A node represents enrichment results of SM-DMRs in a certain chromatin state in a specific cell type or tissue. The node color refers to the direction of enrichment (log2Fold Change), and the size indicates the level of significance. Empirical P value was generated by simulating null distribution of 1000 groups of control areas in the genome. D KEGG pathway enrichment analysis of hypermethylated and hypomethylated DMGs (Top 15 pathways). SM smoking associated, DMR differentially methylated region, DMGs differentially methylated genes, TssA Active TSS, TssAFlnk Flanking Active TSS, TxFlnk Transcr.at gene 5' and 3', Tx Strong transcription, TxWk Weak transcription, EnhG Genic enhancers, Enh Enhancers, ZNF/Rpts ZNF genes & repeats, Het Heterochromatin, TssBiv Bivalent/Poised TSS, BivFlnk Flanking Bivalent TSS/Enh, EnhBiv Bivalent Enhancer, ReprPC Repressed PolyComb, ReprPCWk Weak Repressed PolyComb, Quies Quiescent/Low

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