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Table 1 Clinical characteristics of cohorts used for training, testing and pilot validation of the methylation biomarkers

From: High performance methylated DNA markers for detection of colon adenocarcinoma

Tissue

Training set

Test set

Plasma

Pilot set

Colon ca. (N)

30

33

Colorectal ca. (N)

20

 Age at surgery (years)

  

 Age (years)

 

  Mean

69

69

  Mean

56

  Median

68

69

  Median

58

  Range

55–86

56–85

  Range

40–68

 Sex (N)

  

  Sex (N)

 

  Male

11

19

  Male

11

  Female

19

14

  Female

9

 Tumor cellularity (N)

  0–40%

2

1

  

  ≥ 40–70%

17

16

  

  ≥ 70%

11

16

  

 Stage

  

 Stage

 

  I

7

11

  I

0

  II

11

15

  II

0

  III

12

7

  III

0

  IV

0

0

  IV

20

 Location

  

 Location of Primary

 

  Colon ascendens

14

18

  Colon ascendens

9

  Colon transversum

1

2

  Colon transversum

0

  Colon descendens

3

3

  Colon descendens

2

  Sigmoid

11

10

  Sigmoid

7

  Rectum

0

0

  Rectum

2

  Not available

1

0

  Not available

0

 % Treated (N)

    

  Neoadjuvant

0 (0)

0 (0)

  

  Adjuvant

38.7 (12)

20.6 (7)

  

 Normal, adjacent (N)

23

20

 Normal (N)

20

Age at surgery (years)

  

Age (years)

 

  Mean

66

65

  Mean

70

  Median

65

65

  Median

70

  Range

55–86

56–85

  Range

26–97

 Sex (N)

  

 Sex (N)

 

  Male

11

10

  Male

13

  Female

12

10

  Female

7