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Table 1 Clinical characteristics of cohorts used for training, testing and pilot validation of the methylation biomarkers

From: High performance methylated DNA markers for detection of colon adenocarcinoma

Tissue Training set Test set Plasma Pilot set
Colon ca. (N) 30 33 Colorectal ca. (N) 20
 Age at surgery (years)     Age (years)  
  Mean 69 69   Mean 56
  Median 68 69   Median 58
  Range 55–86 56–85   Range 40–68
 Sex (N)      Sex (N)  
  Male 11 19   Male 11
  Female 19 14   Female 9
 Tumor cellularity (N)
  0–40% 2 1   
  ≥ 40–70% 17 16   
  ≥ 70% 11 16   
 Stage     Stage  
  I 7 11   I 0
  II 11 15   II 0
  III 12 7   III 0
  IV 0 0   IV 20
 Location     Location of Primary  
  Colon ascendens 14 18   Colon ascendens 9
  Colon transversum 1 2   Colon transversum 0
  Colon descendens 3 3   Colon descendens 2
  Sigmoid 11 10   Sigmoid 7
  Rectum 0 0   Rectum 2
  Not available 1 0   Not available 0
 % Treated (N)     
  Neoadjuvant 0 (0) 0 (0)   
  Adjuvant 38.7 (12) 20.6 (7)   
 Normal, adjacent (N) 23 20  Normal (N) 20
Age at surgery (years)    Age (years)  
  Mean 66 65   Mean 70
  Median 65 65   Median 70
  Range 55–86 56–85   Range 26–97
 Sex (N)     Sex (N)  
  Male 11 10   Male 13
  Female 12 10   Female 7