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Table 1 Clinical characteristics of CPA patients with or without pregnancy

From: Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy

Characteristics CPA without pregnancy
(n = 12)
CPA with pregnancy
(n = 4)
P value
Age (years) 30.08 ± 3.11 28.50 ± 2.33 0.783
BMI (kg/m2) 24.90 ± 1.14 27.68 ± 0.69 0.197
SBP (mmHg) 149.83 ± 5.01 152.50 ± 3.66 0.773
DBP (mmHg) 102.00 ± 2.87 97.00 ± 3.08 0.365
Duration of disease (months) 25.92 ± 5.81 4.25 ± 0.85 0.003
K (mmol/L) 3.63 ± 0.15 2.93 ± 0.41 0.057
FSH (IU/L) 5.14 ± 0.49 0.13 ± 0.02  < 0.001
LH (IU/L) 4.00 ± 0.46 0.19 ± 0.03  < 0.001
E2 (pmol/L) 296.48 ± 65.25 7446.43 ± 610.97 0.001
PRL (nmol/L) 86.42 ± 6.49 192.30 ± 48.13 0.002
P (nmol/L) 1.11 ± 0.50 161.70 ± 5.58  < 0.001
HCG (IU/L) 0.27 ± 0.09 45,658.00 ± 9511.54  < 0.001
Cortisol (nmol/L) (8 am) 593.06 ± 51.29 975.35 ± 140.51 0.006
Cortisol (nmol/L) (4 pm) 577.95 ± 44.19 984.74 ± 150.99  < 0.001
Cortisol (nmol/L) (12 pm) 554.11 ± 60.96 935.13 ± 81.89 0.006
ACTH (pmol/L) (8 am)  < 1.00  < 1.00
ACTH (pmol/L) (4 pm)  < 1.00  < 1.00
ACTH (pmol/L) (12 pm)  < 1.00  < 1.00
Tumor size (cm2) 10.31 ± 1.01 10.69 ± 0.80 0.830
Growth rate of tumor (m2/month) 1.00 ± 0.33 2.86 ± 0.57 0.012
  1. Data are mean ± SEM
  2. BMI, Body Mass Index; SBP, Systolic blood pressure; DBP, diastolic blood pressure; K, potassium; FSH, Follicle-stimulating hormone; LH, luteinizing hormone; E2, Estradiol; PRL, prolactin; P, progesterone; HCG, human chorionic gonadotropin; ACTH, adrenocorticotrophic hormone