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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Epigenetic imprinting alterations as effective diagnostic biomarkers for early-stage lung cancer and small pulmonary nodules

Fig. 3

Photomicrographs showing the pathological assessment and confirmation of QCIGISH results. A Comparative analysis of QCIGISH and H&E staining applied on serially resected specimens from the same tissue block of an adenocarcinoma showing increasing imprinted gene SNRPN expression alterations in normal, paracancerous and cancer regions, respectively. The typical normal, paracancerous and cancer regions were all magnified for both QCIGISH and H&E staining. B Illustrated examples showing the visualized allelic expression of imprinted gene GNAS in resected tissue sections of benign lesion and lung cancer subtypes in the model building set. TB, pulmonary tuberculosis. PC, pulmonary cryptococcosis. PIP, pulmonary inflammatory pseudotumor. AdIS, adenocarcinoma in situ. AdC, adenocarcinoma. SqCC, squamous cell carcinoma. LCC, large cell carcinoma. Scale bar, 20 μm

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Clinical Epigenetics

ISSN: 1868-7083

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