Fig. 2
From: Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics
Global longitudinal DNA methylation change in four samples. a PCA plot based on 96 DNA methylation datasets. b Distribution of within-individual reference interval (RI) of each sample. Data for RI ≥ 30 is not represented as the bars were not visible at the present scale. c Box plots showing the relationship between mean and variation of DNA methylation level within three months. d Box plots showing the relationship of between- and within-individual reference intervals in monocytes. Between-individual RI was downloaded from the iMETHYL database which was calculated based on ~ 100 individuals. In each box plot, outliers were depicted as points. e Number of CpG in each category and overlaps between them