Skip to main content

Table 3 Top enriched gene ontology annotations on CpG probes with beta regression coefficient values > 200 in association with ionizing radiations using conditional logistic regression EWAS on the methionine dependency phenotype

From: Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

GO biological process complete

CLR-EWAS for the methionine dependency phenotype (MeWo-LC1 vs. MeWo)

FE*

P-value

FDR, P-value

Centrosome duplication (GO:0051298)

3.16

1.05 × 10–4

7.80 × 10–3

Centrosome cycle (GO:0007098)

2.20

2.11 × 10–4

1.41 × 10–2

Peripheral nervous system development (GO:0007422)

2.17

4.85 × 10–4

2.83 × 10–2

Microtubule organizing center organization (GO:0031023)

2.16

1.22 × 10–4

8.91 × 10–3

response to UV (GO:0,009,411)

2.05

1.53 × 10–5

1.47 × 10–3

Response to ionizing radiation (GO:0010212)

1.94

1.00 × 10–4

7.49 × 10–3

  1. CLR: conditional logistic regression; FE: fold enrichment; DFR: false discovery rate
  2. * Top significantly enriched GO annotations were defined using a Q–Q plot ranking of fold enrichment values. The full list of significantly enriched gene ontology annotations is reported in Additional file 13: Table S7a
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us