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Table 2 Shared gene ontology annotations for enrichment analyses on CpG probes that exhibited a β values difference < − 0.1 before and after ionizing radiation of HepG2, MeWo-LC1, and U251 cell lines

From: Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

GO biological process complete

HepG2*

MeWo-LC1*

U251*

FE

P-value

FDR, P-value

FE

P-value

FDR, P-value

FE

P-value

FDR, P-value

Regulation of neuron projection development (GO:0010975)

2.03

4.69 × 10–6

1.35 × 10–3

2.42

1.05 × 10–5

1.84 × 10–2

2.43

6.78 × 10–5

3.25 × 10–2

Regulation of plasma membrane-bounded cell projection organization (GO:0120035)

1.97

2.76 × 10–7

1.25 × 10–4

2.14

1.58 × 10–5

2.28 × 10–2

2.25

2.07 × 10–5

1.72 × 10–2

Regulation of cell projection organization (GO:0031344)

1.92

6.05 × 10–7

2.33 × 10–4

2.09

3.50 × 10–5

4.25 × 10–2

2.19

4.32 × 10–5

2.53 × 10–2

Nervous system development (GO:0007399)

1.63

6.94 × 10–12

1.22 × 10–8

1.56

1.22 × 10–5

1.93 × 10–2

1.68

1.76 × 10–6

2.53 × 10–3

  1. FE: fold enrichment; DFR: false discovery rate
  2. *No significant GO annotation was found for the CpG probes that exhibited a β values difference < −0.1 before and after ionizing radiation for MeWo cell line