|
CpG
|
Chr
|
Positiona
|
Gene
|
Feature category
|
Cord blood
|
Mid-childhood
|
|---|
| | | | | |
p
|
FDR
|
Median % methylation
|
Mean difference in % methylation (95% CI)
|
p
|
Median % methylation
|
Mean difference in % methylation (95% CI)
|
|---|
|
Mn
| | | | | | | | | | | |
|
All infantsb
| | | | | | | | | | | |
|
cg02042823
|
16
|
6,714,429
|
A2BP1
|
5'UTR
|
2.47 × 10–11
|
9.73 × 10–6
|
98.29
|
2.65 (2.07, 3.23)
|
0.010
|
98.65
|
0.75 (0.14, 1.36)
|
|
Femalec
| | | | | | | | | | | |
|
cg00954161
|
1
|
3,696,925
|
LRRC47
|
3'UTR
|
2.23 × 10–4
|
0.037
|
98.5
|
1.54 (1.08, 2.01)
|
0.001
|
98.41
|
1.33 (0.69, 1.98)
|
|
cg11161853
|
3
|
67,705,044
|
SUCLG2
|
TSS200
|
1.03 × 10–6
|
0.048
|
2.43
|
− 0.32 (− 0.43, − 0.22)
|
0.73
|
2.37
|
0.01 (− 0.06, 0.07)
|
|
cg23903787
|
4
|
3,527,371
|
LRPAP1
|
Body
|
3.13 × 10–7
|
0.038
|
89.44
|
4.60 (3.32, 5.88)
|
0.011
|
89.48
|
2.04 (0.79, 3.29)
|
|
cg19908812
|
4
|
164,253,006
|
NPY1R
|
5'UTR
|
9.36 × 10–7
|
0.048
|
1.47
|
− 0.30 (− 0.38, − 0.21)
|
0.55
|
2.90
|
− 0.03 (− 0.34, 0.27)
|
|
cg26462130
|
7
|
2,052,961
|
MAD1L1
|
Body
|
1.10 × 10–6
|
0.048
|
98.63
|
2.04 (1.67, 2.41)
|
0.005
|
98.71
|
0.98 (0.68, 1.28)
|
|
cg08904630
|
10
|
71,490,427
|
–
| |
9.42 × 10–7
|
0.048
|
97.74
|
0.84 (0.64, 1.04)
|
1.27 × 10–5
|
97.93
|
0.48 (0.34, 0.62)
|
|
cg22799518
|
12
|
56,988,862
|
RBMS2
|
3'UTR
|
3.80 × 10–7
|
0.037
|
98.80
|
2.03 (1.62, 2.44)
|
0.004
|
98.74
|
− 0.20 (− 0.43, 0.03)
|
|
cg01744822
|
16
|
73,100,510
|
–
| |
9.19 × 10–7
|
0.048
|
4.59
|
− 1.16 (− 1.45, − 0.86)
|
9.44 × 10–5
|
8.89
|
− 1.66 (− 2.29, − 1.03)
|
|
cg15712310
|
16
|
73,100,790
|
–
| |
1.93 × 10–7
|
0.037
|
24.87
|
− 2.69 (− 3.56, − 1.81)
|
0.039
|
36.01
|
− 0.97 (− 1.86, − 0.07)
|
|
Maled
| | | | | | | | | | | |
|
cg03763518
|
1
|
150,245,044
|
C1orf54
|
TSS200
|
4.75 × 10–8
|
0.009
|
7.62
|
− 3.01 (− 3.72, − 2.30)
|
1.74 × 10–4
|
32.41
|
− 3.03 (− 4.56, − 1.49)
|
|
cg02042823
|
16
|
6,714,429
|
A2BP1
|
5'UTR
|
2.79 × 10–10
|
1.10 × 10–4
|
98.22
|
3.40 (2.73, 4.07)
|
2.34 × 10–4
|
98.65
|
1.82 (0.51, 3.13)
|
|
Pb
| | | | | | | | | | | |
|
All infants b
| | | | | | | | | | | |
|
cg20608990
|
2
|
202,097,607
|
CASP8
|
TSS1500
|
1.02 × 10–7
|
0.040
|
64.54
|
− 3.10 (− 4.22, − 1.97)
|
0.008
|
48.64%
|
− 1.56 (− 2.73, − 0.40)
|
- Differentially methylated positions (DMPs) identified using models of individual log2-transformed prenatal metal concentration adjusted for infant sex, race/ethnicity, gestational age (age at blood collection for mid-childhood models), nulliparous, maternal age at enrollment, pre-pregnancy BMI, education, smoking, household income, and estimated cord blood cell-type proportions (estimated in cord blood or from leukocytes in mid-childhood). Mean difference in % methylation determined using the same adjusted models for Beta-values for interpretation of results
- ahg 19 assembly
- bCord blood: N = 361; mid-childhood: N = 333
- cFemale (Cord blood: N = 169; mid-childhood: N = 158)
- dMale (Cord blood: N = 192; mid-childhood: N = 175)
