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Table 2 Cord blood differentially methylated positions associated with Mn and Pb (FDR < 0.05)

From: Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals

CpG

Chr

Positiona

Gene

Feature category

Cord blood

Mid-childhood

     

p

FDR

Median % methylation

Mean difference in % methylation (95% CI)

p

Median % methylation

Mean difference in % methylation (95% CI)

Mn

           

 All infantsb

           

 cg02042823

16

6,714,429

A2BP1

5'UTR

2.47 × 10–11

9.73 × 10–6

98.29

2.65 (2.07, 3.23)

0.010

98.65

0.75 (0.14, 1.36)

 Femalec

           

  cg00954161

1

3,696,925

LRRC47

3'UTR

2.23 × 10–4

0.037

98.5

1.54 (1.08, 2.01)

0.001

98.41

1.33 (0.69, 1.98)

  cg11161853

3

67,705,044

SUCLG2

TSS200

1.03 × 10–6

0.048

2.43

− 0.32 (− 0.43, − 0.22)

0.73

2.37

0.01 (− 0.06, 0.07)

  cg23903787

4

3,527,371

LRPAP1

Body

3.13 × 10–7

0.038

89.44

4.60 (3.32, 5.88)

0.011

89.48

2.04 (0.79, 3.29)

  cg19908812

4

164,253,006

NPY1R

5'UTR

9.36 × 10–7

0.048

1.47

− 0.30 (− 0.38, − 0.21)

0.55

2.90

− 0.03 (− 0.34, 0.27)

  cg26462130

7

2,052,961

MAD1L1

Body

1.10 × 10–6

0.048

98.63

2.04 (1.67, 2.41)

0.005

98.71

0.98 (0.68, 1.28)

  cg08904630

10

71,490,427

–

 

9.42 × 10–7

0.048

97.74

0.84 (0.64, 1.04)

1.27 × 10–5

97.93

0.48 (0.34, 0.62)

  cg22799518

12

56,988,862

RBMS2

3'UTR

3.80 × 10–7

0.037

98.80

2.03 (1.62, 2.44)

0.004

98.74

− 0.20 (− 0.43, 0.03)

  cg01744822

16

73,100,510

–

 

9.19 × 10–7

0.048

4.59

− 1.16 (− 1.45, − 0.86)

9.44 × 10–5

8.89

− 1.66 (− 2.29, − 1.03)

  cg15712310

16

73,100,790

–

 

1.93 × 10–7

0.037

24.87

− 2.69 (− 3.56, − 1.81)

0.039

36.01

− 0.97 (− 1.86, − 0.07)

 Maled

           

  cg03763518

1

150,245,044

C1orf54

TSS200

4.75 × 10–8

0.009

7.62

− 3.01 (− 3.72, − 2.30)

1.74 × 10–4

32.41

− 3.03 (− 4.56, − 1.49)

  cg02042823

16

6,714,429

A2BP1

5'UTR

2.79 × 10–10

1.10 × 10–4

98.22

3.40 (2.73, 4.07)

2.34 × 10–4

98.65

1.82 (0.51, 3.13)

Pb

           

 All infants b

           

  cg20608990

2

202,097,607

CASP8

TSS1500

1.02 × 10–7

0.040

64.54

− 3.10 (− 4.22, − 1.97)

0.008

48.64%

− 1.56 (− 2.73, − 0.40)

  1. Differentially methylated positions (DMPs) identified using models of individual log2-transformed prenatal metal concentration adjusted for infant sex, race/ethnicity, gestational age (age at blood collection for mid-childhood models), nulliparous, maternal age at enrollment, pre-pregnancy BMI, education, smoking, household income, and estimated cord blood cell-type proportions (estimated in cord blood or from leukocytes in mid-childhood). Mean difference in % methylation determined using the same adjusted models for Beta-values for interpretation of results
  2. ahg 19 assembly
  3. bCord blood: N = 361; mid-childhood: N = 333
  4. cFemale (Cord blood: N = 169; mid-childhood: N = 158)
  5. dMale (Cord blood: N = 192; mid-childhood: N = 175)
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Clinical Epigenetics

ISSN: 1868-7083

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