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Table 1 Characteristics of selected CpG proxies in neutrophils and pan-lymphocytes

From: Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients

Cell type Probe ID Chromosome Gene name Genic region β-value OR [95% CI]b Padjc AUC [95% CI]
Positiona Cases Controls
Neu cg09993145 1:25291905 RUNX3 TSS1500 0.56 0.51 2.07 [1.60–2.67]  < 1e−04 0.68 [0.64–0.73]
  cg10825315 14:81425912 TSHR Body 0.43 0.40 2.64 [1.80–3.87]  < 1e−04 0.67 [0.62–0.71]
  cg23954655 13:99223562 STK24 Body 0.48 0.44 3.02 [2.07–4.42]  < 1e−04 0.68 [0.63–0.73]
Pan-lym cg04552418 1:31956405 Intergenic 0.36 0.41 0.56 [0.44–0.70]  < 1e−04 0.66 [0.62–0.71]
  cg13580758 4:57824450 REST Body 0.36 0.40 0.58 [0.46–0.74]  < 1e−04 0.64 [0.59–0.69]
  cg26942829 6:13408158 GFOD1 Body 0.36 0.40 0.61 [0.49–0.77]  < 1e−04 0.65 [0.60–0.70]
  1. OR, odds ratio; CI, confidence interval; Padj, adjusted P value; AUC, area under the curve; Neu, neutrophils; Pan-lym, pan-lymphocytes
  2. aHuman GRCh37/hg19 Assembly
  3. bOR is given for a 10% increase in methylation level
  4. cAdjusted for multiple testing using Holm correction