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Table 1 Characteristics of selected CpG proxies in neutrophils and pan-lymphocytes

From: Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients

Cell type

Probe ID

Chromosome

Gene name

Genic region

β-value

OR [95% CI]b

Padjc

AUC [95% CI]

Positiona

Cases

Controls

Neu

cg09993145

1:25291905

RUNX3

TSS1500

0.56

0.51

2.07 [1.60–2.67]

 < 1e−04

0.68 [0.64–0.73]

 

cg10825315

14:81425912

TSHR

Body

0.43

0.40

2.64 [1.80–3.87]

 < 1e−04

0.67 [0.62–0.71]

 

cg23954655

13:99223562

STK24

Body

0.48

0.44

3.02 [2.07–4.42]

 < 1e−04

0.68 [0.63–0.73]

Pan-lym

cg04552418

1:31956405

Intergenic

–

0.36

0.41

0.56 [0.44–0.70]

 < 1e−04

0.66 [0.62–0.71]

 

cg13580758

4:57824450

REST

Body

0.36

0.40

0.58 [0.46–0.74]

 < 1e−04

0.64 [0.59–0.69]

 

cg26942829

6:13408158

GFOD1

Body

0.36

0.40

0.61 [0.49–0.77]

 < 1e−04

0.65 [0.60–0.70]

  1. OR, odds ratio; CI, confidence interval; Padj, adjusted P value; AUC, area under the curve; Neu, neutrophils; Pan-lym, pan-lymphocytes
  2. aHuman GRCh37/hg19 Assembly
  3. bOR is given for a 10% increase in methylation level
  4. cAdjusted for multiple testing using Holm correction