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Table 2 Significant sites associated with body mass index * metabolic health Z score interaction (BMIxMHZ) including the effect size for the higher-level variables

From: Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes

CpG site Effect size (BMI × MHZ) Standard error Z score P value FDR q value Direction Effect size (BMI) Effect size (MHZ)
cg24827562 − 8.71E−05 9.83E−06 − 8.41E+00 3.98E−17 1.70E−11 −+++− 9.27E−06 0.00161952
cg02851049 − 8.85E−05 1.04E−05 − 7.91E+00 2.53E−15 5.39E−10 ++−+− − 8.49E−06 0.00126491
cg22076143 − 1.01E−04 1.27E−05 − 7.62E+00 2.55E−14 3.63E−09 −+++− − 1.47E−06 0.00119747
cg20210586 − 1.03E−04 1.39E−05 − 6.97E+00 3.28E−12 3.49E−07 −−++− 1.38E−05 0.00237264
cg18989722 − 8.36E−05 1.20E−05 − 6.54E+00 6.14E−11 4.86E−06 −+−+− − 5.73E−06 0.00139622
cg15062225 − 1.38E−04 2.05E−05 − 6.52E+00 6.83E−11 4.86E−06 −+−+− 8.86E−05 0.00309348
cg24460625 − 7.26E−05 1.11E−05 − 6.38E+00 1.80E−10 1.10E−05 −+−+− 2.29E−06 0.00186604
cg10057841 − 9.86E−05 1.56E−05 − 5.99E+00 2.04E−09 1.09E−04 −−−+− 3.25E−05 0.0020491
cg06344952 − 9.11E−05 1.46E−05 − 5.79E+00 7.23E−09 3.43E−04 −−−+− 5.91E−05 0.00307032
cg26206680 − 6.13E−05 9.90E−06 − 5.73E+00 9.98E−09 4.26E−04 ++−+− − 7.74E−06 0.00014127
cg27004639 5.20E−05 9.14E−06 5.64E+00 1.66E−08 6.34E−04 +−+−+ 4.21E−05 − 0.0017364
cg19572849 − 4.99E−05 8.96E−06 − 5.63E+00 1.78E−08 6.34E−04 −+++− − 1.67E−05 0.00155317
cg08082299 − 1.01E−04 1.73E−05 − 5.59E+00 2.25E−08 7.37E−04 −+++− − 1.49E−05 0.00209263
cg18298785 − 8.52E−05 1.40E−05 − 5.58E+00 2.42E−08 7.37E−04 −+++− − 2.99E−07 0.00212176
cg16543390 6.71E−05 1.38E−05 5.26E+00 1.46E−07 4.16E−03 −+−++ 3.05E−05 − 0.0022199
cg16461485 − 1.15E−04 2.06E−05 − 5.23E+00 1.71E−07 4.34E−03 −+−+− 8.27E-05 0.00151377
cg21880445 − 7.90E−05 1.44E−05 − 5.23E+00 1.73E−07 4.34E−03 −+++− − 3.03E−05 0.00174726
cg07226317 − 9.17E−05 1.62E−05 − 5.16E+00 2.53E−07 6.00E−03 −+−+− 3.12E−05 0.00135378
cg05441596 − 5.74E−05 1.11E−05 − 4.95E+00 7.39E−07 1.62E−02 ++++− 3.48E−05 0.00106747
cg24720717 6.22E−05 1.22E−05 4.95E+00 7.59E−07 1.62E−02 ++−−+ − 7.25E−06 − 0.002551
cg11553983 − 6.96E−05 1.36E−05 − 4.76E+00 1.94E−06 3.88E−02 +−−+− 3.50E−05 0.00075824
cg00868074 3.15E−04 6.90E−05 4.75E+00 2.00E−06 3.88E−02 +++++ − 0.0003756 − 0.0140558
  1. Direction of effect has been included for the individual ancillary studies from the WHI, Women’s Health Initiative; EMPC, epigenetic mechanisms of particulate matter-mediated cardiovascular disease; BAA23, the integrative genomics for risk of coronary heart disease and related phenotypes in WHI cohort; AS311, bladder cancer and leukocyte methylation; ARIC, the Atherosclerosis Risk in Communities Study; EA, European American; AA, African American, respectively