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Table 2 Significant sites associated with body mass index * metabolic health Z score interaction (BMIxMHZ) including the effect size for the higher-level variables

From: Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes

CpG site

Effect size (BMI × MHZ)

Standard error

Z score

P value

FDR q value

Direction

Effect size (BMI)

Effect size (MHZ)

cg24827562

− 8.71E−05

9.83E−06

− 8.41E+00

3.98E−17

1.70E−11

−+++−

9.27E−06

0.00161952

cg02851049

− 8.85E−05

1.04E−05

− 7.91E+00

2.53E−15

5.39E−10

++−+−

− 8.49E−06

0.00126491

cg22076143

− 1.01E−04

1.27E−05

− 7.62E+00

2.55E−14

3.63E−09

−+++−

− 1.47E−06

0.00119747

cg20210586

− 1.03E−04

1.39E−05

− 6.97E+00

3.28E−12

3.49E−07

−−++−

1.38E−05

0.00237264

cg18989722

− 8.36E−05

1.20E−05

− 6.54E+00

6.14E−11

4.86E−06

−+−+−

− 5.73E−06

0.00139622

cg15062225

− 1.38E−04

2.05E−05

− 6.52E+00

6.83E−11

4.86E−06

−+−+−

8.86E−05

0.00309348

cg24460625

− 7.26E−05

1.11E−05

− 6.38E+00

1.80E−10

1.10E−05

−+−+−

2.29E−06

0.00186604

cg10057841

− 9.86E−05

1.56E−05

− 5.99E+00

2.04E−09

1.09E−04

−−−+−

3.25E−05

0.0020491

cg06344952

− 9.11E−05

1.46E−05

− 5.79E+00

7.23E−09

3.43E−04

−−−+−

5.91E−05

0.00307032

cg26206680

− 6.13E−05

9.90E−06

− 5.73E+00

9.98E−09

4.26E−04

++−+−

− 7.74E−06

0.00014127

cg27004639

5.20E−05

9.14E−06

5.64E+00

1.66E−08

6.34E−04

+−+−+

4.21E−05

− 0.0017364

cg19572849

− 4.99E−05

8.96E−06

− 5.63E+00

1.78E−08

6.34E−04

−+++−

− 1.67E−05

0.00155317

cg08082299

− 1.01E−04

1.73E−05

− 5.59E+00

2.25E−08

7.37E−04

−+++−

− 1.49E−05

0.00209263

cg18298785

− 8.52E−05

1.40E−05

− 5.58E+00

2.42E−08

7.37E−04

−+++−

− 2.99E−07

0.00212176

cg16543390

6.71E−05

1.38E−05

5.26E+00

1.46E−07

4.16E−03

−+−++

3.05E−05

− 0.0022199

cg16461485

− 1.15E−04

2.06E−05

− 5.23E+00

1.71E−07

4.34E−03

−+−+−

8.27E-05

0.00151377

cg21880445

− 7.90E−05

1.44E−05

− 5.23E+00

1.73E−07

4.34E−03

−+++−

− 3.03E−05

0.00174726

cg07226317

− 9.17E−05

1.62E−05

− 5.16E+00

2.53E−07

6.00E−03

−+−+−

3.12E−05

0.00135378

cg05441596

− 5.74E−05

1.11E−05

− 4.95E+00

7.39E−07

1.62E−02

++++−

3.48E−05

0.00106747

cg24720717

6.22E−05

1.22E−05

4.95E+00

7.59E−07

1.62E−02

++−−+

− 7.25E−06

− 0.002551

cg11553983

− 6.96E−05

1.36E−05

− 4.76E+00

1.94E−06

3.88E−02

+−−+−

3.50E−05

0.00075824

cg00868074

3.15E−04

6.90E−05

4.75E+00

2.00E−06

3.88E−02

+++++

− 0.0003756

− 0.0140558

  1. Direction of effect has been included for the individual ancillary studies from the WHI, Women’s Health Initiative; EMPC, epigenetic mechanisms of particulate matter-mediated cardiovascular disease; BAA23, the integrative genomics for risk of coronary heart disease and related phenotypes in WHI cohort; AS311, bladder cancer and leukocyte methylation; ARIC, the Atherosclerosis Risk in Communities Study; EA, European American; AA, African American, respectively