Maternal characteristics | |
Age, y | 32.0 (4.0) |
Educational level | |
No, primary, secondary, n (%) | 353 (32.0) |
College or higher, n (%) | 749 (68.0) |
Pre-pregnancy body mass index, kg/m2 | 22.3 (18.5, 34.1) |
Folic acid supplementation during pregnancy | |
No supplementation, n (%) | 62 (6.8) |
Started before 10 weeks, n (%) | 282 (31.2) |
Started preconception, n (%) | 561 (62.0) |
Smoking during pregnancy | |
Non-smoker or smoked until pregnancy was known, n (%) | 900 (88.5) |
Smoked throughout pregnancy, n (%) | 117 (11.5) |
Pregnancy dating based on last menstrual period | |
No, n (%) | 297 (26.6) |
Yes, n (%) | 818 (73.4) |
Self-reported hypertension | |
No, n (%) | 971 (99.1) |
Yes, n (%) | 9 (0.9) |
Family history of cardiovascular diseaseb | |
No, n (%) | 533 (54.2) |
Yes, n (%) | 451 (45.8) |
Birth characteristics | |
Clinical gestational age, wk | 40.2 (37.0, 42.4) |
DNA methylation gestational age (Bohlin), wk | 39.4 (37.2, 40.8) |
Raw gestational age acceleration (Bohlin), wk | − 0.90 (− 2.76, 0.92) |
Residual gestational age acceleration (Bohlin), wk | 0.03 (− 1.24, 1.09) |
DNA methylation gestational age (Knight), wk | 36.5 (32.4, 39.3) |
Raw gestational age acceleration (Knight), wk | − 3.70 (− 7.44, − 1.07) |
Residual gestational age acceleration (Knight), wk | 0.15 (− 3.34, 2.63) |
Sex | |
Boy, n (%) | 544 (48.8) |
Girl, n (%) | 571 (51.2) |
Childhood characteristics | |
At 6 y | |
Age at visitc, y | 6.0 (5.7, 7.0) |
DNA methylation age (Skin and blood), y | 5.6 (4.3, 7.9) |
Raw age acceleration (Skin and blood), y | − 0.39 (1.7, 1.7) |
Residual age acceleration (Skin and blood), y | − 0.03 (− 1.3, 2.1) |
Blood pressure, mmHg | |
Systolic | 102 (7.7) |
Diastolic | 60 (6.3) |
At 10 y | |
Age at visit, y | |
Children with DNA methylation data at birth | 9.8 (9.3, 10.5) |
Children with DNA methylation data at 10 yd | 9.8 (9.2, 10.3) |
DNA methylation age (Skin and blood), y | 8.5 (6.7, 11.5) |
Raw age acceleration (Skin and blood), y | − 1.2 (− 3.0, 1.8) |
Residual age acceleration (Skin and blood), y | − 0.10 (− 1.9, 2.8) |
Blood pressure, mmHg | |
Systolic | 103 (7.7) |
Diastolic | 58 (6.2) |
Common carotid artery intima-media thickness, mm | 0.45 (0.04) |
Common carotid artery distensibilitye, kPa−1*10–3 | 56.0 (37.3, 85.0) |