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Table 7 Gene Ontology enrichment analysis

From: Epigenetic adaptations of the masticatory mucosa to periodontal inflammation

Sub-ontology

Gene ontology term

N genes in GO term

N differentially methylated genes (%)*

punadj

BP

inactivation of X chromosome by genetic imprinting

3

3 (100.0%)

4.3 × 10–5

BP

synaptic vesicle cycle

191

18 (9.4%)

9.0 × 10–5

CC

hippocampal mossy fiber to CA3 synapse

33

7 (21.2%)

9.7 × 10–5

BP

vesicle-mediated transport in synapse

211

18 (8.5%)

3.0 × 10–4

MF

small conductance calcium-activated potassium channel activity

4

3 (75.0%)

3.1 × 10–4

BP

synaptic vesicle fusion to presynaptic active zone membrane

22

5 (22.7%)

3.5 × 10–4

CC

neuron projection

1298

64.5 (5.0%)

3.6 × 10–4

BP

vesicle fusion to plasma membrane

23

5 (21.7%)

4.0 × 10–4

BP

chemical synaptic transmission

699

40.5 (5.8%)

5.1 × 10–4

BP

anterograde trans-synaptic signaling

699

40.5 (5.8%)

5.1 × 10–4

BP

metanephric renal vesicle formation

4

3 (75.0%)

5.2 × 10–4

BP

neurotransmitter secretion

169

15 (8.9%)

5.8 × 10–4

BP

signal release from synapse

169

15 (8.9%)

5.8 × 10–4

BP

trans-synaptic signaling

707

40.5 (5.7%)

6.5 × 10–4

CC

synaptic vesicle

190

15 (7.9%)

6.7 × 10–4

MF

calcium-activated potassium channel activity

15

4 (26.7%)

8.1 × 10–4

MF

glutamate receptor activity

27

6 (22.2%)

9.7 × 10–4

BP

synaptic signaling

724

40.5 (5.6%)

9.9 × 10–4

  1. Most significant gene ontology (GO) terms (p < 0.001) for genes corresponding to the 2347 DMPs significant in the full and paired sub-analysis. None of the pathways was significant after correction for multiple testing (FDR). *numbers are adjusted for probe-number bias and annotation to multiple genes by using a fractional count [19]. BP = biological process; MF = molecular function; CC = cellular component