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Table 7 Gene Ontology enrichment analysis

From: Epigenetic adaptations of the masticatory mucosa to periodontal inflammation

Sub-ontology Gene ontology term N genes in GO term N differentially methylated genes (%)* punadj
BP inactivation of X chromosome by genetic imprinting 3 3 (100.0%) 4.3 × 10–5
BP synaptic vesicle cycle 191 18 (9.4%) 9.0 × 10–5
CC hippocampal mossy fiber to CA3 synapse 33 7 (21.2%) 9.7 × 10–5
BP vesicle-mediated transport in synapse 211 18 (8.5%) 3.0 × 10–4
MF small conductance calcium-activated potassium channel activity 4 3 (75.0%) 3.1 × 10–4
BP synaptic vesicle fusion to presynaptic active zone membrane 22 5 (22.7%) 3.5 × 10–4
CC neuron projection 1298 64.5 (5.0%) 3.6 × 10–4
BP vesicle fusion to plasma membrane 23 5 (21.7%) 4.0 × 10–4
BP chemical synaptic transmission 699 40.5 (5.8%) 5.1 × 10–4
BP anterograde trans-synaptic signaling 699 40.5 (5.8%) 5.1 × 10–4
BP metanephric renal vesicle formation 4 3 (75.0%) 5.2 × 10–4
BP neurotransmitter secretion 169 15 (8.9%) 5.8 × 10–4
BP signal release from synapse 169 15 (8.9%) 5.8 × 10–4
BP trans-synaptic signaling 707 40.5 (5.7%) 6.5 × 10–4
CC synaptic vesicle 190 15 (7.9%) 6.7 × 10–4
MF calcium-activated potassium channel activity 15 4 (26.7%) 8.1 × 10–4
MF glutamate receptor activity 27 6 (22.2%) 9.7 × 10–4
BP synaptic signaling 724 40.5 (5.6%) 9.9 × 10–4
  1. Most significant gene ontology (GO) terms (p < 0.001) for genes corresponding to the 2347 DMPs significant in the full and paired sub-analysis. None of the pathways was significant after correction for multiple testing (FDR). *numbers are adjusted for probe-number bias and annotation to multiple genes by using a fractional count [19]. BP = biological process; MF = molecular function; CC = cellular component