Skip to main content

Table 4 DMPs associated with padj < 10–5 in the paired sub-analysis after stringent filtering

From: Epigenetic adaptations of the masticatory mucosa to periodontal inflammation

Probe ID Chr:Position (hg19) Distance to nearest significant DMP (bp) Sup-porting DMPs (n) Gene Symbol Median TPM* p (full analysis) q (full analysis) padj (paired analysis) β (full analysis) Raw beta values (mean)
Uninflamed (n = 48) Inflamed (n = 48) pGECs (n = 5) Blood* (n = 69)
cg00320534 chr10:22,216,647 201 1 DNAJC1 391 1.3 × 10–15 1.0 × 10–9 9.1 × 10–6 − 0.20 0.88 0.75 0.24 0.92
cg12891342 chr11:58,344,244 90 5 LPXN 64 4.3 × 10–8 3.4 × 10–2 1.4 × 10–5 − 0.20 0.79 0.6 0.83 0.88
cg07215395 chr5:115,148,221 1251 1 CDO1 12 1.3 × 10–14 9.9 × 10–9 2.9 × 10–5 − 0.20 0.83 0.62 0.80 0.90
cg11470748 chr15:92,378,414 102 1 SLCO3A1 482 2.1 × 10–8 1.6 × 10–2 4.1 × 10–5 − 0.18 0.64 0.55 0.67 0.90
cg07994786 chr16:48,389,355 409 1 LONP2 1010 3.5 × 10–10 2.7 × 10–4 4.7 × 10–5 − 0.15 0.86 0.78 0.88 0.95
cg02099194 chr13:43,149,689 34 1 TNFSF11 1 4.8 × 10–12 3.8 × 10–6 6.3 × 10–5 − 0.19 0.36 0.18 0.46 0.27
cg25157850 chr20:62,401,287 78 2 ZBTB46 29 8.4 × 10–10 6.5 × 10–4 6.5 × 10–5 − 0.23 0.77 0.62 0.68 0.91
cg08446539 chr12:25,541,565 201 1 KRAS/LMNTD1 730 / 0 9.1 × 10–12 7.1 × 10–6 6.5 × 10–5 − 0.24 0.79 0.5 0.81 0.75
cg06142324 chr11:124,805,538 425 1 HEPACAM 0 1.8 × 10–11 1.4 × 10–5 7.8 × 10–5 − 0.13 0.85 0.77 0.82 0.93
cg18038139 chr17:10,560,748 72 2 MYH3 24 1.3 × 10–8 9.8 × 10–3 8.0 × 10–5 − 0.20 0.7 0.55 0.75 0.90
cg19705197 chr10:6,264,090 606 1 PFKFB3 408 3.6 × 10–12 2.8 × 10–6 8.2 × 10–5 − 0.20 0.74 0.69 0.68 0.93
cg10254357 chr1:95,592,493 162 1 TMEM56 22 4.4 × 10–12 3.4 × 10–6 8.4 × 10–5 − 0.20 0.8 0.64 0.76 0.89
cg09083279 chr6:29,454,873 15 2 MAS1L 0 4.9 × 10–12 3.8 × 10–6 8.9 × 10–5 − 0.27 0.56 0.34 0.37 0.63
  1. DMPs meeting the following filter criteria: q < 0.05, effect sizes ≥ 0.1, distance to nearest significant (q < 0.05) DMP \(\le\) 2 kb (= supporting DMP), padj < 10–5 in paired analysis (n = 39), ranked according to their padj in the paired analysis. p Values from paired analysis are Bonferroni-corrected for 15,507 tests. ∆β-values are adjusted according to our intercept method [16]. *mRNA-sequencing in healthy keratinized oral mucosa with 16mio reads/sample [12]. **downloaded from GSE123914 [54]. DMP = differentially methylated position, bp = basepairs, TPM = transcripts per million pGECs = primary gingival epithelial cells