Table 2 Most significant DMPs in full analysis that were also significant in the paired sub-analysis
From: Epigenetic adaptations of the masticatory mucosa to periodontal inflammation
Probe ID | Chr:Position (hg19) | Distance to nearest significant DMP (bp) | Gene Symbol | Median TPM* | p (full analysis) | q (full analysis) | padj (paired analysis) | ∆β (full analysis) | Raw beta values (mean) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Uninflamed (n = 48) | Inflamed (n = 48) | pGECs (n = 5) | Blood (n = 69)** | |||||||||
cg23278359 | chr8:142,439,128 | 131 | PTP4A3 | 78 | 2.2 × 10–18 | 1.8 × 10–12 | 0.01 | − 0.18 | 0.87 | 0.8 | 0.8 | 0.93 |
cg17282085 | chr3:77,684,050 | 455,069 | ROBO2 | 239 | 6.2 × 10–18 | 4.9 × 10–12 | 8.8 × 10–3 | − 0.14 | 0.81 | 0.48 | 0.55 | 0.57 |
cg06819431 | chr1:153,605,367 | 25,710 | CHTOP | 701 | 6.6 × 10–18 | 5.2 × 10–12 | 1.3 × 10–4 | − 0.16 | 0.89 | 0.78 | 0.89 | 0.93 |
cg25428009 | chr8:126,304,221 | 194,357 | NSMCE2 | 263 | 7.0 × 10–18 | 5.5 × 10–12 | 1.0 × 10–4 | − 0.05 | 0.89 | 0.69 | 0.88 | 0.67 |
cg24469152 | chr20:62,378,611 | 7815 | ZBTB46 | 29 | 8.5 × 10–18 | 6.7 × 10–12 | 0.03 | − 0.11 | 0.87 | 0.88 | 0.86 | 0.96 |
cg06405792 | chr19:36,483,062 | 60,585 | SDHAF1 | 153 | 1.8 × 10–17 | 1.4 × 10–11 | 7.1 × 10–4 | − 0.13 | 0.88 | 0.81 | 0.89 | 0.92 |
cg15834202 | chr5:58,865,918 | 38,967 | PDE4D | 79 | 3.1 × 10–17 | 2.4 × 10–11 | 4.4 × 10–5 | − 0.28 | 0.77 | 0.45 | 0.65 | 0.61 |
cg27288968 | chr21:34,106,765 | 116,334 | PAXBP1 | 310 | 3.2 × 10–17 | 2.6 × 10–11 | 9.5 × 10–4 | − 0.27 | 0.82 | 0.64 | 0.82 | 0.87 |
cg17835169 | chr5:149,281,308 | 58,550 | PDE6A | 16 | 3.3 × 10–17 | 2.6 × 10–11 | 1.0 × 10–3 | − 0.19 | 0.88 | 0.6 | 0.93 | 0.75 |
cg21500126 | chr8:119,372,894 | 186,008 | SAMD12 | 214 | 4.9 × 10–17 | 3.9 × 10–11 | 6.7 × 10–5 | − 0.24 | 0.79 | 0.6 | 0.8 | 0.84 |
cg02967821 | chr8:30,582,335 | 18,888 | GSR | 671 | 4.9 × 10–17 | 3.9 × 10–11 | 8.7 × 10–5 | − 0.23 | 0.89 | 0.79 | 0.81 | 0.91 |
cg17423032 | chr5:31,755,265 | 23,874 | PDZD2 | 1696 | 1.9 × 10–16 | 1.5 × 10–10 | 3.6 × 10–4 | − 0.15 | 0.89 | 0.77 | 0.91 | 0.93 |
cg19962349 | chr5:43,534,107 | 69,246 | PAIP1 | 1157 | 2.3 × 10–16 | 1.8 × 10–10 | 2.0 × 10–5 | − 0.25 | 0.67 | 0.5 | 0.75 | 0.74 |
cg16084117 | chr20:47,188,436 | 49,123 | TRNA_Pseudo | NA | 3.3 × 10–16 | 2.6 × 10–10 | 2.8 × 10–3 | − 0.14 | 0.91 | 0.78 | 0.92 | NA |
cg01379678 | chr18:32,397,156 | 6921 | DTNA | 11 | 4.1 × 10–16 | 3.2 × 10–10 | 1.2 × 10–5 | − 0.17 | 0.85 | 0.72 | 0.88 | 0.93 |
cg11022756 | chr4:170,540,250 | 6371 | CLCN3 | 2771 | 6.0 × 10–16 | 4.8 × 10–10 | 6.9 × 10–3 | − 0.14 | 0.83 | 0.75 | 0.85 | 0.92 |
cg00414647 | chr19:40,781,453 | 57,065 | AKT2 | 2076 | 7.7 × 10–16 | 6.0 × 10–10 | 0.01 | − 0.06 | 0.9 | 0.76 | 0.92 | 0.82 |
cg27597264 | chr6:8,086,870 | 232 | SCARNA27 | NA | 9.1 × 10–16 | 7.1 × 10–10 | 1.5 × 10–4 | − 0.20 | 0.85 | 0.7 | 0.87 | 0.89 |
cg27168410 | chr19:41,629,018 | 1528 | CYP2F1 | 41 | 9.3 × 10–16 | 7.4 × 10–10 | 6.2 × 10–3 | − 0.21 | 0.88 | 0.71 | 0.89 | 0.9 |
cg16302962 | chr8:131,124,760 | 187,033 | ASAP1 | 623 | 9.7 × 10–16 | 7.7 × 10–10 | 0.02 | − 0.23 | 0.85 | 0.62 | 0.92 | 0.84 |