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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Associations between indicators of socioeconomic position and DNA methylation: a scoping review

Fig. 1

Systematic search and selection procedure. The full search and selection procedure of published studies from inception through September 2019 for a systematic review of the association between socioeconomic position (SEP) and DNA methylation (DNAm). A PubMed and PsycINFO search returned 478 articles. Abstracts were assessed and most articles (n = 366) were excluded because they did not include an SEP measure as an exposure and/or did not include DNAm as an outcome. Thirteen articles only measured “epigenetic age,” or estimates of biological age based on DNAm, and were also removed. Another 10 were removed because they did not include a healthy control group or their sample was homogenous for SEP level (e.g., entirely low income). Four animal studies were removed. Three studies were excluded because they combined SEP and non-SEP (e.g., childhood abuse) measures into one aggregated composite measure. Fifty-five were reviews, overviews, or commentaries and were also excluded. We identified six additional studies by reviewing reference lists of 29 eligible publications and added two known publications to the review. In final, 37 studies were included in this systematic review. Note: Excluded studies do not sum to 449 due to overlap

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