Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Table 1 Characteristics of participants in each data set included in the DNA methylation meta-analysis

FUSION	Females, n = 115^a	Males, n = 159^a	p value^b
Age (years)	61 (8)	59 (8)	0.2
Health			0.026
Healthy	93 (81%)	109 (69%)
T2D	22 (19%)	50 (31%)

Gene SMART	Females, n = 20^a	Males, n = 45^a	p value^b
Age (years)	35 (7)	32 (8)	0.1
Health
Healthy	20 (100%)	45 (100%)

GSE38291	Females, n = 12^a	Males, n = 10^a	p value^b
Age (years)	66 (9)	70 (4)	0.15
Health
Healthy	6 (50%)	5 (50%)
T2D	6 (50%)	5 (50%)

Statistics shown for differences between males and females. The comparison of healthy and diabetic males and females tested whether males and females was equally represented in each group.
^aMean (SD); n (%)
^bWelch two-sample t-test

ISSN: 1868-7083