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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Fig. 5

Integration of differentially methylated genes and differentially expressed genes. a Venn diagram of the overlap between differentially methylated genes (DMGs; derived from DMRs), differentially expressed genes derived from GTEx (DEGs GTEx), and differentially expressed genes derived from FUSION (DEGs FUSION) between males and females. b Subset of 12 genes with consistently large effect sizes or of biological relevance to skeletal muscle. c Correlation between the effect sizes of DMRs in enhancer regions and the effect sizes of gene expression of the relative annotated gene (for GTEx sex-biased genes). Quadrant percentages indicate the percentage DMRs/DEGs that fall into each quadrant. d Correlation between the effect sizes of DMRs in promoter regions and the effect sizes of gene expression of the relative annotated gene (for GTEx sex-biased genes). Quadrant percentages indicate the percentage DMRs/DEGs that fall into each quadrant

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Clinical Epigenetics

ISSN: 1868-7083

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