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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

Fig. 3

Genomic context of sex-differentially methylated positions. a Distribution of hyper-/hypo-DMPs and non-DMPs with respect to chromatin states (male skeletal muscle annotation). Blue is hypomethylated in males and red is hypermethylated in males. Red and blue add up to all of the sex-DMPs. Black denotes the rest of the CpG sites from the analysis which are not DMPs. Asterisks represent a greater contribution to the significant relationship between DMP status and chromatin state (Additional file 1: Figure S1A). b Distribution of sex-DMPs and non-DMPs at loci whose chromatin states differ between male and female skeletal muscle. Purple denotes all DMPs (hypo and hyper combined) and black denotes non-DMPs. c Distribution of sex-DMPs and non-DMPs in relation to CpG islands. Asterisks represent a greater contribution to the significant relationship between DMP status and CpG island location (Additional file 1: Figure S1B). d Bee swarm plot showing enrichment of transcription factor binding sites (TFBSs)(−(log10(p value) using Fisher’s exact tests) on the y-axis for differentially methylated positions (DMPs) according to UniBind [45]. The names of the top 10 enriched TFs are denoted by the colour key; brown denotes non-significant TFs. The various data sets for the same TFs are graphed with the corresponding colour

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