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Table 1 Dataset characteristics used in model building, internal and external validation

From: Validating biomarkers and models for epigenetic inference of alcohol consumption from blood

Study N Age (years), mean (SD) Men (%) BMI mean (SD) Alcohol gr/day, Median (min, max) Non-drinkers (%) Light drinkers (%) At-risk drinkers (%) Heavy drinkers (%)
Model building and internal validation dataset
RS-II-3/III-2 611 67 (6) 275 (45) 27.8 (4) 8.6 (1, 57) 0 (0) 545 (89) 52 (9) 14 (2)
CODAM 159 66 (7) 86 (54) 28.9 (4) 7.9 (0, 72) 12 (8) 117 (74) 23 (14) 7 (4)
NTR 617 39 (14) 188 (31) 24.6 (4) 5.1 (0, 69) 195 (32) 348 (56) 44 (7) 30 (5)
LLS 491 58 (6) 231 (47) 25.3 (3) 13.0 (0, 90) 36 (7) 309 (63) 98 (20) 49 (10)
PAN 164 62 (9) 100 (61) 26.0 (4) 11.0 (0, 77) 1 (1) 127 (77) 20 (12) 16 (10)
KORA F4 841 61 (9) 415 (49) 28.0 (5) 7.6 (0, 150) 251 (30) 354 (42) 133 (16) 103 (12)
Total dataset 2883 57 (14) 1295 (45) 26.7 (4) 8.0 (0, 150) 495 (17) 1800 (62) 370 (13) 218 (8)
External validation datasets
SHIP-Trend 433 51 (14) 205 (47) 27.2 (4.1) 3.6 (0, 82) 47 (11) 346 (80) 28 (6) 12 (3)
TwinsUK 713 58 (10) 0 (0) 26.7 (5) 2.3 (0, 101) 187 (26) 423 (59) 67 (9) 36 (5)
TwinsUK2 442 59 (9) 0 (0) 26.6 (5) 5.3 (0, 94) 36 (8) 311 (70) 46 (10) 49 (11)
RS-III-1 648 59.6 (8) 298 (46) 27.7 (5) 6.4 (0, 57) 64 (10) 495 (76) 79 (12) 10 (2)
  1. The total model building dataset was also used for internal ten-fold cross-validation. BMI, body mass index; CODAM, Cohort on Diabetes and Atherosclerosis Maastricht; KORA F4, The Cooperative Health Research in the Region of Augsburg study; LLS, Leiden Longevity Study; NTR, Netherlands Twin Register; PAN, Prospective ALS Study Netherlands; RS, Rotterdam Study; SD, standard deviation; SHIP, Study of Health in Pomerania-Trend cohort; TwinsUK, The TwinsUK Study; TwinsUK2, Subset of the TwinsUK Study. The alcohol categories were defined as; non-drinkers were defined as participants with no alcohol consumption; light drinkers with an alcohol consumption of 0 < g per day 28 in men and 0 < g per day 14 in women; and heavy drinkers with an alcohol consumption of 42 g per day in men and 28 g per day in women